The neuroprotective effects of targeting key factors of neuronal cell death in neurodegenerative diseases: The role of ER stress, oxidative stress, and …

MS Karvandi, F Sheikhzadeh Hesari… - Frontiers in Cellular …, 2023 - frontiersin.org
Neuronal loss is one of the striking causes of various central nervous system (CNS)
disorders, including major neurodegenerative diseases, such as Alzheimer's disease (AD) …

Pharmacotherapy evolution in Alzheimer's disease: current framework and relevant directions

DC Miculas, PA Negru, SG Bungau, T Behl, SS Hassan… - Cells, 2022 - mdpi.com
Alzheimer's disease (AD), once considered a rare disease, is now the most common form of
dementia in the elderly population. Current drugs (cholinesterase inhibitors and glutamate …

Levetiracetam mechanisms of action: from molecules to systems

IJ Contreras-García, N Cárdenas-Rodríguez… - Pharmaceuticals, 2022 - mdpi.com
Epilepsy is a chronic disease that affects millions of people worldwide. Antiepileptic drugs
(AEDs) are used to control seizures. Even though parts of their mechanisms of action are …

The link between oxidative stress, mitochondrial dysfunction and neuroinflammation in the pathophysiology of Alzheimer's disease: therapeutic implications and future …

MC Jurcău, FL Andronie-Cioara, A Jurcău, F Marcu… - Antioxidants, 2022 - mdpi.com
Alzheimer's disease (AD), the most common form of dementia, has increasing incidence,
increasing mortality rates, and poses a huge burden on healthcare. None of the currently …

Intracellular molecular targets and signaling pathways involved in antioxidative and neuroprotective effects of cannabinoids in neurodegenerative conditions

A Tadijan, I Vlašić, J Vlainić, D Đikić, N Oršolić… - Antioxidants, 2022 - mdpi.com
In the last few decades, endocannabinoids, plant-derived cannabinoids and synthetic
cannabinoids have received growing interest as treatment options in neurodegenerative …

Moringa oleifera: A Tree of Life as a Promising Medicinal Plant for Neurodegenerative Diseases

S Ghimire, L Subedi, N Acharya… - Journal of agricultural …, 2021 - ACS Publications
Moringa oleifera, popularly known as a miracle tree or tree of life, has been extensively used
as a functional food and nutritional asset worldwide. Ethnomedicinal and traditional uses of …

[HTML][HTML] Oxidative stress, the blood–brain barrier and neurodegenerative diseases: The critical beneficial role of dietary antioxidants

J Feng, Y Zheng, M Guo, I Ares, M Martínez… - … Pharmaceutica Sinica B, 2023 - Elsevier
In recent years, growing awareness of the role of oxidative stress in brain health has
prompted antioxidants, especially dietary antioxidants, to receive growing attention as …

Polysaccharide-based electroconductive hydrogels: Structure, properties and biomedical applications

MK Yazdi, P Zarrintaj, A Khodadadi, A Arefi, F Seidi… - Carbohydrate …, 2022 - Elsevier
Architecting an appropriate platform for biomedical applications requires setting a balance
between simplicity and complexity. Polysaccharides (PSAs) play essential roles in our life in …

Anti-oxidative, anti-inflammatory and anti-apoptotic effects of flavonols: targeting Nrf2, NF-κB and p53 pathways in neurodegeneration

M Jazvinšćak Jembrek, N Oršolić, L Mandić, A Sadžak… - Antioxidants, 2021 - mdpi.com
Neurodegenerative diseases are one of the leading causes of disability and death
worldwide. Intracellular transduction pathways that end in the activation of specific …

Rhus coriaria L. (Sumac), a Versatile and Resourceful Food Spice with Cornucopia of Polyphenols

GES Batiha, OM Ogunyemi, HM Shaheen, FR Kutu… - Molecules, 2022 - mdpi.com
In recent years, utilization of Rhus coriaria L.(sumac) is upgrading not only in their culinary
use and human nutrition, but also in the pharmaceutical industry, food industry and …