Pathogenic mechanisms of lipid mediator lysophosphatidic acid in chronic pain
H Ueda - Progress in lipid research, 2021 - Elsevier
A number of membrane lipid-derived mediators play pivotal roles in the initiation,
maintenance, and regulation of various types of acute and chronic pain. Acute pain …
maintenance, and regulation of various types of acute and chronic pain. Acute pain …
Cytochrome P450 eicosanoids in cerebrovascular function and disease
Cytochrome P450 eicosanoids play important roles in brain function and disease through
their complementary actions on cell-cell communications within the neurovascular unit …
their complementary actions on cell-cell communications within the neurovascular unit …
[HTML][HTML] Epoxide hydrolase 1 (EPHX1) hydrolyzes epoxyeicosanoids and impairs cardiac recovery after ischemia
Stimuli such as inflammation or hypoxia induce cytochrome P450 epoxygenase-mediated
production of arachidonic acid–derived epoxyeicosatrienoic acids (EETs). EETs have …
production of arachidonic acid–derived epoxyeicosatrienoic acids (EETs). EETs have …
Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain
M Sisignano, C Angioni, CK Park… - Proceedings of the …, 2016 - National Acad Sciences
Chemotherapy-induced peripheral neuropathic pain (CIPNP) is a severe dose-and therapy-
limiting side effect of widely used cytostatics that is particularly difficult to treat. Here, we …
limiting side effect of widely used cytostatics that is particularly difficult to treat. Here, we …
Anti-inflammatory dopamine-and serotonin-based endocannabinoid epoxides reciprocally regulate cannabinoid receptors and the TRPV1 channel
The endocannabinoid system is a promising target to mitigate pain as the
endocannabinoids are endogenous ligands of the pain-mediating receptors—cannabinoid …
endocannabinoids are endogenous ligands of the pain-mediating receptors—cannabinoid …
Cytochrome P450 oxidase 2J inhibition suppresses choroidal neovascularization in mice
Introduction Choroidal neovascularization (CNV) in age-related macular degeneration
(AMD) leads to blindness. It has been widely reported that increased intake of ω− 3 long …
(AMD) leads to blindness. It has been widely reported that increased intake of ω− 3 long …
Fatty acid metabolite profiling reveals oxylipins as markers of brown but not brite adipose tissue
S Dieckmann, S Maurer, T Fromme, C Colson… - Frontiers in …, 2020 - frontiersin.org
Metabolites of omega-6 and omega-3 polyunsaturated fatty acids are important signaling
molecules implicated in the control of adipogenesis and energy balance regulation. Some of …
molecules implicated in the control of adipogenesis and energy balance regulation. Some of …
A Lipidomic Analysis of Docosahexaenoic Acid (22:6, ω3) Mediated Attenuation of Western Diet Induced Nonalcoholic Steatohepatitis in Male Ldlr -/- Mice
Nonalcoholic fatty liver disease (NAFLD) is a major public health problem worldwide.
NAFLD ranges in severity from benign steatosis to nonalcoholic steatohepatitis (NASH) …
NAFLD ranges in severity from benign steatosis to nonalcoholic steatohepatitis (NASH) …
Emerging roles for brain drug-metabolizing cytochrome P450 enzymes in neuropsychiatric conditions and responses to drugs
F Toselli, PR Dodd, EMJ Gillam - Drug metabolism reviews, 2016 - Taylor & Francis
P450s in the human brain were originally considered unlikely to contribute significantly to
the clearance of drugs and other xenobiotic chemicals, since their overall expression was a …
the clearance of drugs and other xenobiotic chemicals, since their overall expression was a …
[HTML][HTML] Expression of Cyp2c/Cyp2j subfamily members and oxylipin levels during LPS-induced inflammation and resolution in mice
JP Graves, JA Bradbury, A Gruzdev, H Li… - The FASEB …, 2019 - ncbi.nlm.nih.gov
Inflammatory stimuli, such as bacterial LPS, alter the expression of many cytochromes P450.
CYP2C and CYP2J subfamily members actively metabolize fatty acids to bioactive …
CYP2C and CYP2J subfamily members actively metabolize fatty acids to bioactive …