Natural product compounds have recently attracted significant attention from the scientific
community for their potent effects against inflammation-driven diseases, including cancer. A …

The pursuit of matrix metalloproteinase (MMP) inhibitors began in earnest over three
decades ago. Initial clinical trials were disappointing, resulting in a negative view of MMPs …

Since the identification of matrix metalloproteinases (MMPs), a family of zinc-dependent
endopeptidases, as being a driving factor for cancer progression and patient prognosis …

Albumin has shown remarkable promise as a natural drug carrier by improving
pharmacokinetic (PK) profiles of anticancer drugs for tumor-targeted delivery. The …

Perineural invasion (PNI) is a prominent characteristic of pancreatic cancer. PNI is a process
whereby cancer cells invade the surrounding nerves, thus providing an alternative route for …

The proteolytic processing of collagen (collagenolysis) is critical in development and
homeostasis, but also contributes to numerous pathologies. Mammalian interstitial …

Mesothelin (MSLN) and cancer antigen125/mucin 16 (CA125/MUC16) are potential
biomarkers for pancreatic cancer (PC) that are co-overexpressed at the invading edges of …

Angiogenesis is facilitated by the proteolytic activities of members of the matrix
metalloproteinase (MMP) family. More specifically, MMP-9 and MT1-MMP directly regulate …

With the discovery of cisplatin, a vast area of applications of metallodrugs in cancer
treatment was opened but due to the side effects caused by the cisplatin complexes …

Pancreatic cancer remains a challenging disease with an overall cumulative 5-year survival
rate below 1%. The process of cancer initiation, progression and metastasis is still not …