Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer, which will
affect more than a million people by the year 2025. However, current treatment options have …

Coronary artery disease (CAD) remains the leading cause of adult mortality globally.
Targeting known modifiable risk factors has had substantial benefit, but there remains a …

Coronary atherosclerosis results from the delicate interplay of genetic and exogenous risk
factors, principally taking place in metabolic organs and the arterial wall. Here we show that …

Abstract Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are effective, well-tolerated,
and safe glucose-lowering compounds for patients with type 2 diabetes mellitus (T2DM) …

Regulation of the reaction pathways is a perennial theme in the field of chemistry. As a
typical chromogenic substrate, 3, 3′, 5, 5′-tetramethylbenzidine (TMB) generally …

Abstract Background Type 2 Diabetes (T2D) diagnosis is based solely on glycaemia, even
though it is an endpoint of numerous dysmetabolic pathways. Type 2 Diabetes complexity is …

A goal of medical research is to determine the molecular basis of human brain health and
illness. One way to achieve this goal is through observational studies of gene expression in …

The catalytic activities of currently developed peroxidase-mimic nanozymes are generally
limited. Therefore, further efforts are still needed to improve the catalytic performance of …

It'sa challenge for detecting the therapeutic targets of a polypharmacological drug from
variations in the responsed networks in the differentiated populations with complex …

Senescent cells are a major contributor to age-dependent cardiovascular tissue dysfunction,
but knowledge of their in vivo cell markers and tissue context is lacking. To reveal tissue …