[HTML][HTML] MicroRNAs: synthesis, mechanism, function, and recent clinical trials

F Wahid, A Shehzad, T Khan, YY Kim - Biochimica et Biophysica Acta (BBA …, 2010 - Elsevier
MicroRNAs (miRNAs) are a class of small, endogenous RNAs of 21–25 nucleotides (nts) in
length. They play an important regulatory role in animals and plants by targeting specific …

RNA silencing as a plant immune system against viruses

O Voinnet - TRENDS in Genetics, 2001 - cell.com
Abstract 'RNA silencing'refers to related processes of post-trancriptional control of gene
expression found in plants, animals and fungi. A unifying feature of RNA silencing is that it …

A Cellular Function for the RNA-Interference Enzyme Dicer in the Maturation of the let-7 Small Temporal RNA

G Hutvagner, J McLachlan, AE Pasquinelli, É Bálint… - Science, 2001 - science.org
The 21-nucleotide small temporal RNA (stRNA) let-7 regulates developmental timing in
Caenorhabditis elegans and probably in other bilateral animals. We present in vivo and in …

MicroRNAs in plants

BJ Reinhart, EG Weinstein, MW Rhoades… - Genes & …, 2002 - genesdev.cshlp.org
MicroRNAs (miRNAs) are an extensive class of∼ 22-nucleotide noncoding RNAs thought to
regulate gene expression in metazoans. We find that miRNAs are also present in plants …

Prediction of plant microRNA targets

MW Rhoades, BJ Reinhart, LP Lim, CB Burge, B Bartel… - cell, 2002 - cell.com
We predict regulatory targets for 14 Arabidopsis microRNAs (miRNAs) by identifying mRNAs
with near complementarity. Complementary sites within predicted targets are conserved in …

Temporal regulation of shoot development in Arabidopsis thalianaby miR156 and its target SPL3

G Wu, RS Poethig - 2006 - journals.biologists.com
SPL3, SPL4 and SPL5 (SPL3/4/5) are closely related members of the SQUAMOSA
PROMOTER BINDING PROTEIN-LIKE family of transcription factors in Arabidopsis, and …

[HTML][HTML] Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

SM Elbashir, J Martinez, A Patkaniowska… - The EMBO …, 2001 - embopress.org
Duplexes of 21–23 nucleotide (nt) RNAs are the sequence‐specific mediators of RNA
interference (RNAi) and post‐transcriptional gene silencing (PTGS). Synthetic, short …

CARPEL FACTORY, a Dicer homolog, and HEN1, a novel protein, act in microRNA metabolism in Arabidopsis thaliana

W Park, J Li, R Song, J Messing, X Chen - Current biology, 2002 - cell.com
Background: In metazoans, microRNAs, or miRNAs, constitute a growing family of small
regulatory RNAs that are usually 19–25 nucleotides in length. They are processed from …

P1/HC-Pro, a viral suppressor of RNA silencing, interferes with Arabidopsis development and miRNA function

KD Kasschau, Z **e, E Allen, C Llave, EJ Chapman… - Developmental cell, 2003 - cell.com
The molecular basis for virus-induced disease in plants has been a long-standing mystery.
Infection of Arabidopsis by Turnip mosaic virus (TuMV) induces a number of developmental …

On the origin and functions of RNA-mediated silencing: from protists to man

H Cerutti, JA Casas-Mollano - Current genetics, 2006 - Springer
Double-stranded RNA has been shown to induce gene silencing in diverse eukaryotes and
by a variety of pathways. We have examined the taxonomic distribution and the phylogenetic …