Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …

Janus kinase/signal transduction and transcription activation (JAK/STAT) pathways were
originally thought to be intracellular signaling pathways that mediate cytokine signals in …

There are four members of the JAK family and seven of the STAT family in mammals. The
JAK/STAT molecular pathway could be activated by broad hormones, cytokines, growth …

Cardiovascular disease is a leading cause of death worldwide and there is a pressing need
for new therapeutic strategies to treat such conditions. The risk of develo** cardiovascular …

The intact heart undergoes complex and multiscale remodelling processes in response to
altered mechanical cues. Remodelling of the myocardium is regulated by a combination of …

Cellular therapy for myocardial injury has improved ventricular function in both animal and
clinical studies, though the mechanism of benefit is unclear. This study was undertaken to …

Atherosclerosis is the main pathological basis of ischemic cardiovascular and
cerebrovascular diseases and has attracted more attention in recent years. Multiple studies …

Cardiac hypertrophy is a well known response to increased hemodynamic load. Mechanical
stress is considered to be the trigger inducing a growth response in the overloaded …

MicroRNAs are endogenously expressed small noncoding RNAs that regulate gene
expression on the posttranscriptional level. The miR-17-92 cluster (encoding miR-17,-18a …

Signal transducer and activator of transcription 3 (STAT3) is a signaling molecule and
transcription factor that plays important protective roles in the heart. The protection mediated …