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[HTML][HTML] Epigenetic alterations in cancer
Genetic and epigenetic modifications in DNA contribute to altered gene expression in aging
and cancer. In human cancers, epigenetic changes such as DNA methylation, histone …
and cancer. In human cancers, epigenetic changes such as DNA methylation, histone …
Fanconi anaemia and cancer: an intricate relationship
Fanconi anaemia (FA) is a genetic disorder that is characterized by bone marrow failure
(BMF), developmental abnormalities and predisposition to cancer. Together with other …
(BMF), developmental abnormalities and predisposition to cancer. Together with other …
A first-in-class polymerase theta inhibitor selectively targets homologous-recombination-deficient tumors
DNA polymerase theta (POLθ or POLQ) is synthetic lethal with homologous recombination
(HR) deficiency and is thus a candidate target for HR-deficient cancers. Through high …
(HR) deficiency and is thus a candidate target for HR-deficient cancers. Through high …
Germline and somatic mutations in homologous recombination genes predict platinum response and survival in ovarian, fallopian tube, and peritoneal carcinomas
Purpose: Hallmarks of germline BRCA1/2-associated ovarian carcinomas include
chemosensitivity and improved survival. The therapeutic impact of somatic BRCA1/2 …
chemosensitivity and improved survival. The therapeutic impact of somatic BRCA1/2 …
Defects in DNA repair genes predict response to neoadjuvant cisplatin-based chemotherapy in muscle-invasive bladder cancer
Background Cisplatin-based neoadjuvant chemotherapy (NAC) before cystectomy is the
standard of care for muscle-invasive bladder cancer (MIBC), with 25–50% of patients …
standard of care for muscle-invasive bladder cancer (MIBC), with 25–50% of patients …
The DNA damage response: implications for tumor responses to radiation and chemotherapy
Cellular responses to DNA damage are important determinants of both cancer development
and cancer outcome following radiation therapy and chemotherapy. Identification of …
and cancer outcome following radiation therapy and chemotherapy. Identification of …
DNA interstrand crosslink repair and cancer
Interstrand crosslinks (ICLs) are highly toxic DNA lesions that prevent transcription and
replication by inhibiting DNA strand separation. Agents that induce ICLs were one of the …
replication by inhibiting DNA strand separation. Agents that induce ICLs were one of the …
DNA methylation profiling in the clinic: applications and challenges
Abstract Knowledge of epigenetic alterations in disease is rapidly increasing owing to the
development of genome-wide techniques for their identification. The ever-growing number …
development of genome-wide techniques for their identification. The ever-growing number …
“Platinum resistant” ovarian cancer: what is it, who to treat and how to measure benefit?
Abstract “Platinum resistant” ovarian cancer was historically defined as disease recurrence
within 6 months of completion of first-line platinum-based chemotherapy, although this is …
within 6 months of completion of first-line platinum-based chemotherapy, although this is …
Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition
Genomic instability can initiate cancer, augment progression, and influence the overall
prognosis of the affected patient. Genomic instability arises from many different pathways …
prognosis of the affected patient. Genomic instability arises from many different pathways …