All endocrine glands are susceptible to neoplastic growth, yet the health consequences of
these neoplasms differ between endocrine tissues. Pituitary neoplasms are highly prevalent …

The 4th edition of the World Health Organization (WHO) classification of endocrine tumors
has been recently released. In this new edition, major changes are recommended in several …

Background Pituitary tumours are common and easily treated by surgery or medical
treatment in most cases. However, a small subset of pituitary tumours does not respond to …

This review focuses on discussing the main changes on the upcoming fourth edition of the
WHO Classification of Tumors of the Pituitary Gland emphasizing histopathological and …

Context Somatic mutations in the ubiquitin-specific peptidase USP8 gene were recently
detected in one-to two-third (s) of corticotroph adenomas of Cushing's disease (CD). These …

Non-tumoural cells within the tumour microenvironment (TME) influence tumour
proliferation, invasiveness and angiogenesis. Little is known about TME in pituitary …

Objective and design A clinicopathological score has been proposed by Trouillas et al. to
predict the evolution of pituitary adenomas. Aim of our study was to perform an independent …

Recurrence and biochemical remission rates vary widely among different histological
subtypes of pituitary adenoma. In this prospective study, we evaluated 107 consecutive …

Pituitary tumors are not rare if prevalence rates from autopsy or radiological series are
considered; approximately 0.5% of all pituitary adenomas will come to medical attention …

Brain cancer is a disease caused by the growth of abnormal aggressive cells in the brain
outside of normal cells. Symptoms and diagnosis of brain cancer cases are producing more …