RNA ac4C modification is a novel and rare chemical modification observed in mRNA.
Traditional biochemical studies had primarily associated ac4C modification with tRNA and …

Alternative splicing (AS) serves as a pivotal mechanism in transcriptional regulation,
engendering transcript diversity, and modifications in protein structure and functionality …

N 4-Acetylcytidine (ac4C) has been found to affect a variety of cellular and biological
processes. For a mechanistic understanding of the roles of ac4C in biology and disease, we …

The quick progress of epigenetic study has kindled new hope for treating many cancers.
When it comes to RNA epigenetics, the ac4C acetylation modification is showing promise …

RNA modification has emerged as an important epigenetic mechanism that controls
abnormal metabolism and growth in acute myeloid leukaemia (AML). However, the roles of …

Cardiovascular disease (CVD) is the leading cause of death in the world, with a high
incidence and a youth-oriented tendency. RNA modification is ubiquitous and indispensable …

The oldest known highly conserved modification of RNA, N4-acetylcytidine, is widely
distributed from archaea to eukaryotes and acts as a posttranscriptional chemical …

BACKGROUND: Cardiac hypertrophy and its associated remodeling are among the leading
causes of heart failure. Lysine crotonylation is a recently discovered posttranslational …

Sepsis-associated encephalopathy (SAE) is a critical neurological complication of sepsis
and represents a crucial factor contributing to high mortality and adverse prognosis in septic …

Abstract Background and Aims Vascular smooth muscle cell (VSMC) phenotype switching is
a pathological hallmark in various cardiovascular diseases. N4-acetylcytidine (ac4C) …