Proteasome is a multi-subunit protein degradation machine, which plays a key role in the
maintenance of protein homeostasis and, through degradation of regulatory proteins, in the …

Protein homeostasis (proteostasis) disturbances and inflammation are evident in normal
aging and some age-related neurodegenerative diseases. While the proteostasis network …

Neuropathology in the human autoimmune disease multiple sclerosis (MS) is considered to
be mediated by autoreactive leukocytes, such as T cells, B cells, and macrophages …

The proteasome system degrades more than 80% of intracellular proteins into small
peptides. Accordingly, the proteasome is involved in many essential cellular functions, such …

CD8+ T cell specificity depends on the recognition of MHC class I–epitope complexes at the
cell surface. These epitopes are mainly produced via degradation of proteins by the …

Caspase-1 activation by inflammasome signaling scaffolds initiates inflammation and
antimicrobial responses. Caspase-1 proteolytically converts newly induced pro-interleukin 1 …

The wealth of recent evidence about a bi-directional communication between nerve-and
immune-cells revolutionized the traditional concept about the brain as an “immune …

Intrinsically disordered myelin basic protein (MBP) is one of the key autoantigens in
autoimmune neurodegeneration and multiple sclerosis particularly. MBP is highly positively …

The immunoproteasome is a specialized form of proteasome equipped with modified
catalytic subunits that was initially discovered to play a pivotal role in MHC class I antigen …

Simple Summary Immunoproteasome plays a key role in the generation of antigenic
peptides. Immune checkpoints therapy is a front-line treatment of advanced/metastatic …