The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy

HH Han, HM Wang, P Jangili, M Li, L Wu… - Chemical Society …, 2023 - pubs.rsc.org
Cancer remains as one of the most significant health problems, with approximately 19
million people diagnosed worldwide each year. Chemotherapy is a routinely used method to …

Activity‐based smart AIEgens for detection, bioimaging, and therapeutics: Recent progress and outlook

H Li, H Kim, J Han, VN Nguyen, X Peng, J Yoon - Aggregate, 2021 - Wiley Online Library
Activity‐based approaches for designing AIEgens possess prominent advantages including
high selectivity, sensitivity, and signal‐to‐noise ratio, and they have received more attention …

Theranostic fluorescent probes

A Sharma, P Verwilst, M Li, D Ma, N Singh… - Chemical …, 2024 - ACS Publications
The ability to gain spatiotemporal information, and in some cases achieve spatiotemporal
control, in the context of drug delivery makes theranostic fluorescent probes an attractive …

Prodrug-inspired adenosine triphosphate–activatable celastrol-Fe (III) chelate for cancer therapy

H Li, Y Li, L Zhang, N Wang, D Lu, D Tang, Y Lv… - Science …, 2024 - science.org
Celastrol (CEL), an active compound isolated from the root of Tripterygium wilfordii, exhibits
broad anticancer activities. However, its poor stability, narrow therapeutic window and …

Immunosonodynamic therapy designed with activatable sonosensitizer and immune stimulant imiquimod

H Lei, JH Kim, S Son, L Chen, Z Pei, Y Yang, Z Liu… - ACS …, 2022 - ACS Publications
Sonodynamic therapy (SDT) has garnered extensive attention as a noninvasive treatment
for deep tumors. Furthermore, imiquimod (R837), an FDA-approved toll-like receptor 7 …

Aminopeptidase N Activatable Fluorescent Probe for Tracking Metastatic Cancer and Image-Guided Surgery via in Situ Spraying

H Li, Q Yao, W Sun, K Shao, Y Lu… - Journal of the …, 2020 - ACS Publications
The recurrence of malignant tumors is mostly caused by incompleted surgical resection.
Especially, it is difficult for surgeons to detect and accurately remove metastatic tumors by …

Visualization nanozyme based on tumor microenvironment “unlocking” for intensive combination therapy of breast cancer

Z Wang, Z Li, Z Sun, S Wang, Z Ali, S Zhu, S Liu… - Science …, 2020 - science.org
Nanozymes as artificial enzymes that mimicked natural enzyme–like activities have received
great attention in cancer therapy. However, it remains a great challenge to design …

Rationally designed polymer conjugate for tumor-specific amplification of oxidative stress and boosting antitumor immunity

S Ma, W Song, Y Xu, X Si, S Lv, Y Zhang, Z Tang… - Nano Letters, 2020 - ACS Publications
The crosstalk between tumor and stroma cells is a central scenario in the tumor
microenvironment (TME). While the predominant effect of tumor cells on immune cells is …

Targeted photodynamic therapy using a water-soluble aggregation-Induced emission photosensitizer activated by an acidic tumor microenvironment

X Min, F Yi, XL Han, M Li, Q Gao, X Liang… - Chemical Engineering …, 2022 - Elsevier
Abstract Aggregation-induced emission (AIE)-active photosensitizers (PSs) are considered
as a kind of promising functionalized materials for photodynamic therapy of tumor. Improving …

Engineering prodrug nanomedicine for cancer immunotherapy

B Yang, J Gao, Q Pei, H Xu, H Yu - Advanced Science, 2020 - Wiley Online Library
Immunotherapy has shifted the clinical paradigm of cancer management. However, despite
promising initial progress, immunotherapeutic approaches to cancer still suffer from …