The design of small-molecule prodrugs and activatable phototherapeutics for cancer therapy
Cancer remains as one of the most significant health problems, with approximately 19
million people diagnosed worldwide each year. Chemotherapy is a routinely used method to …
million people diagnosed worldwide each year. Chemotherapy is a routinely used method to …
Activity‐based smart AIEgens for detection, bioimaging, and therapeutics: Recent progress and outlook
Activity‐based approaches for designing AIEgens possess prominent advantages including
high selectivity, sensitivity, and signal‐to‐noise ratio, and they have received more attention …
high selectivity, sensitivity, and signal‐to‐noise ratio, and they have received more attention …
Theranostic fluorescent probes
The ability to gain spatiotemporal information, and in some cases achieve spatiotemporal
control, in the context of drug delivery makes theranostic fluorescent probes an attractive …
control, in the context of drug delivery makes theranostic fluorescent probes an attractive …
Prodrug-inspired adenosine triphosphate–activatable celastrol-Fe (III) chelate for cancer therapy
H Li, Y Li, L Zhang, N Wang, D Lu, D Tang, Y Lv… - Science …, 2024 - science.org
Celastrol (CEL), an active compound isolated from the root of Tripterygium wilfordii, exhibits
broad anticancer activities. However, its poor stability, narrow therapeutic window and …
broad anticancer activities. However, its poor stability, narrow therapeutic window and …
Immunosonodynamic therapy designed with activatable sonosensitizer and immune stimulant imiquimod
Sonodynamic therapy (SDT) has garnered extensive attention as a noninvasive treatment
for deep tumors. Furthermore, imiquimod (R837), an FDA-approved toll-like receptor 7 …
for deep tumors. Furthermore, imiquimod (R837), an FDA-approved toll-like receptor 7 …
Aminopeptidase N Activatable Fluorescent Probe for Tracking Metastatic Cancer and Image-Guided Surgery via in Situ Spraying
The recurrence of malignant tumors is mostly caused by incompleted surgical resection.
Especially, it is difficult for surgeons to detect and accurately remove metastatic tumors by …
Especially, it is difficult for surgeons to detect and accurately remove metastatic tumors by …
Visualization nanozyme based on tumor microenvironment “unlocking” for intensive combination therapy of breast cancer
Z Wang, Z Li, Z Sun, S Wang, Z Ali, S Zhu, S Liu… - Science …, 2020 - science.org
Nanozymes as artificial enzymes that mimicked natural enzyme–like activities have received
great attention in cancer therapy. However, it remains a great challenge to design …
great attention in cancer therapy. However, it remains a great challenge to design …
Rationally designed polymer conjugate for tumor-specific amplification of oxidative stress and boosting antitumor immunity
The crosstalk between tumor and stroma cells is a central scenario in the tumor
microenvironment (TME). While the predominant effect of tumor cells on immune cells is …
microenvironment (TME). While the predominant effect of tumor cells on immune cells is …
Targeted photodynamic therapy using a water-soluble aggregation-Induced emission photosensitizer activated by an acidic tumor microenvironment
X Min, F Yi, XL Han, M Li, Q Gao, X Liang… - Chemical Engineering …, 2022 - Elsevier
Abstract Aggregation-induced emission (AIE)-active photosensitizers (PSs) are considered
as a kind of promising functionalized materials for photodynamic therapy of tumor. Improving …
as a kind of promising functionalized materials for photodynamic therapy of tumor. Improving …
Engineering prodrug nanomedicine for cancer immunotherapy
B Yang, J Gao, Q Pei, H Xu, H Yu - Advanced Science, 2020 - Wiley Online Library
Immunotherapy has shifted the clinical paradigm of cancer management. However, despite
promising initial progress, immunotherapeutic approaches to cancer still suffer from …
promising initial progress, immunotherapeutic approaches to cancer still suffer from …