Many lines of evidence support that β-amyloid (Aβ) peptides play an important role in
Alzheimer's disease (AD), the most common cause of dementia. But despite much effort the …

Aging is accompanied by cognitive decline in a major segment of the population and is the
primary risk factor for Alzheimer's disease and other prevalent neurodegenerative disorders …

The aberrant accumulation of aggregated β-amyloid peptides (Aβ) as plaques is a hallmark
of Alzheimer's disease (AD) neuropathology and reduction of Aβ has become a leading …

Alzheimer's disease (AD) is a highly prevalent neurodegenerative disorder characterized by
a progressive loss of cognition and the presence of two hallmark lesions, senile plaques …

J. Neurochem.(2012) 120 (Suppl. 1), 149–166. Abstract The biggest risk factor for
Alzheimer's disease is the process of ageing, but the mechanisms that lead to the …

The “Amyloid Cascade Hypothesis” has dominated the Alzheimer's disease (AD) field in the
last 25 years. It posits that the increase of amyloid-ß (Aß) is the key event in AD that triggers …

The neuropathology associated with Alzheimer's disease (AD) is characterized by the
presence of extracellularly neuritic plaques, intracellularly neurofibrillary tangles and the …

Amyloid aggregation is a hallmark of several degenerative diseases affecting the brain or
peripheral tissues, whose intermediates (oligomers, protofibrils) and final mature fibrils …

The concurrent application of subtoxic doses of soluble oligomeric forms of human amyloid-
beta (oAβ) and Tau (oTau) proteins impairs memory and its electrophysiological surrogate …

It is widely accepted that amyloid β (Aβ) generated from amyloid precursor protein (APP)
oligomerizes and fibrillizes to form neuritic plaques in Alzheimer's disease (AD), yet little is …