Insects possess a cuticle that covers all tissues exposed to the outside world including the
body, the fore-and hindgut and the luminal side of the tracheae. The cuticle is a …

Historically, Drosophila has been a model organism for studying molecular and
developmental biology leading to many important discoveries in this field. More recently, the …

Establishment and maintenance of proper architecture is essential for endoplasmic
reticulum (ER) function. Homotypic membrane fusion is required for ER biogenesis and …

Periodic pulses of the insect steroid molting hormone 20‐hydroxyecdysone (20E), acting via
its nuclear receptor complex (EcR/USP), control gene expression at many stages throughout …

Secretory pathways within dendrites of neurons have been proposed for local transport of
newly synthesized proteins. However, little is known about the dynamics of the local …

Many cells store neutral lipids, as triacylglycerol and sterol esters, in droplets. PAT-domain
proteins form a conserved family of proteins that are localized at the surface of neutral lipid …

Here, we describe that depletion of the Drosophila homologue of p115 (dp115) by RNA
interference in Drosophila S2 cells led to important morphological changes in the Golgi …

Regulated secretion of hormones, digestive enzymes, and other biologically active
molecules requires the formation of secretory granules. Clathrin and the clathrin adaptor …

A striking variety of glycosylation occur in the Golgi complex in a protein-specific manner, but
how this diversity and specificity are achieved remains unclear. Here we show that stacked …

Secretory cargos are collected at endoplasmic reticulum (ER) exit sites (ERES) before
transport to the Golgi apparatus. Decades of research have provided many details of the …