Current preclinical studies in drug development utilize high-throughput in vitro screens to
identify drug leads, followed by both in vitro and in vivo models to predict lead candidates' …

We address the question of ultimate selective advantages of hibernation. Biologists
generally seem to accept the notion that multiday torpor is primarily a response to adverse …

For the last century we have relied on model organisms to help understand fundamental
biological processes. Now, with advancements in genome sequencing, assembly, and …

Genomics encompasses the entire tree of life, both extinct and extant, and the evolutionary
processes that shape this diversity. To date, genomic research has focused on humans, a …

Species that hibernate generally live longer than would be expected based solely on their
body size. Hibernation is characterized by long periods of metabolic suppression (torpor) …

Over 15 families of aquatic plants are known to use a strategy of developmental switching
upon environmental stress to produce dormant propagules called turions. However, few …

Changes correlating with increasing obesity include insulin resistance, hyperlipidaemia,
hyperinsulinaemia, highly processed food and environmental toxins including plastics and …

Some vertebrates evolved to have a remarkable capacity for anatomical and physiological
plasticity in response to environmental challenges. One example of such plasticity can be …

Hibernators dramatically lower metabolism to save energy while fasting for months.
Prolonged fasting challenges metabolic homeostasis, yet small-bodied hibernators emerge …

Tissue-resident stem cells may enter a dormant state, also known as quiescence, which
allows them to withstand metabolic stress and unfavorable conditions. Similarly, hibernating …