Research priorities for an HIV cure: international AIDS society global scientific strategy 2021
Despite the success of antiretroviral therapy (ART) for people living with HIV, lifelong
treatment is required and there is no cure. HIV can integrate in the host genome and persist …
treatment is required and there is no cure. HIV can integrate in the host genome and persist …
Targeting the latent reservoir for HIV-1
S Sengupta, RF Siliciano - Immunity, 2018 - cell.com
Antiretroviral therapy can effectively block HIV-1 replication and prevent or reverse
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …
Evidence for HIV-1 cure after CCR5Δ32/Δ32 allogeneic haemopoietic stem-cell transplantation 30 months post analytical treatment interruption: a case report
Summary Background The London patient (participant 36 in the IciStem cohort) underwent
allogeneic stem-cell transplantation with cells that did not express CCR5 (CCR5Δ32/Δ32); …
allogeneic stem-cell transplantation with cells that did not express CCR5 (CCR5Δ32/Δ32); …
HIV persistence in tissue macrophages of humanized myeloid-only mice during antiretroviral therapy
JB Honeycutt, WO Thayer, CE Baker, RM Ribeiro… - Nature medicine, 2017 - nature.com
Despite years of fully suppressive antiretroviral therapy (ART), HIV persists in its hosts and is
never eradicated. One major barrier to eradication is that the virus infects multiple cell types …
never eradicated. One major barrier to eradication is that the virus infects multiple cell types …
HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study
Background It is unknown if extremely early initiation of antiretroviral therapy (ART) may lead
to long-term ART-free HIV remission or cure. As a result, we studied 2 individuals recruited …
to long-term ART-free HIV remission or cure. As a result, we studied 2 individuals recruited …
Engineering HIV-resistant, anti-HIV chimeric antigen receptor T cells
The treatment or cure of HIV infection by cell and gene therapy has been a goal for decades.
Recent advances in both gene editing and chimeric antigen receptor (CAR) technology …
Recent advances in both gene editing and chimeric antigen receptor (CAR) technology …
Astrocytes are HIV reservoirs in the brain: a cell type with poor HIV infectivity and replication but efficient cell‐to‐cell viral transfer
The major barrier to eradicating Human immunodeficiency virus‐1 (HIV) infection is the
generation of tissue‐associated quiescent long‐lasting viral reservoirs refractory to therapy …
generation of tissue‐associated quiescent long‐lasting viral reservoirs refractory to therapy …
A 4-days-on and 3-days-off maintenance treatment strategy for adults with HIV-1 (ANRS 170 QUATUOR): a randomised, open-label, multicentre, parallel, non …
Background Intermittent (on 4 days per week) antiretroviral therapy (ART) for patients with
HIV-1 might be more convenient, better tolerated, and cheaper than continuous treatment …
HIV-1 might be more convenient, better tolerated, and cheaper than continuous treatment …
Insights into persistent HIV-1 infection and functional cure: novel capabilities and strategies
TM Ta, S Malik, EM Anderson, AD Jones… - Frontiers in …, 2022 - frontiersin.org
Although HIV-1 replication can be efficiently suppressed to undetectable levels in peripheral
blood by combination antiretroviral therapy (cART), lifelong medication is still required in …
blood by combination antiretroviral therapy (cART), lifelong medication is still required in …
Venetoclax, alone and in combination with the BH3 mimetic S63845, depletes HIV-1 latently infected cells and delays rebound in humanized mice
P Arandjelovic, Y Kim, JP Cooney, SP Preston… - Cell Reports …, 2023 - cell.com
HIV-1 persists indefinitely in people living with HIV (PLWH) on antiretroviral therapy (ART). If
ART is stopped, the virus rapidly rebounds from long-lived latently infected cells. Using a …
ART is stopped, the virus rapidly rebounds from long-lived latently infected cells. Using a …