Advances in genomics technology have provided the means to probe myriad chromatin
interactions at unprecedented spatial and temporal resolution. This has led to a profound …

The compaction of genomic DNA into chromatin has profound implications for the regulation
of key processes such as transcription, replication and DNA repair. Nucleosomes, the …

Nucleosomes are important for gene regulation because their arrangement on the genome
can control which proteins bind to DNA. Currently, few human nucleosomes are thought to …

Regulation of gene expression in eukaryotes is an extremely complex process. In this
review, we break down several critical steps, emphasizing new data and techniques that …

Chromatin is a highly regulated, modular nucleoprotein complex that is central to many
processes in eukaryotes. The organization of DNA into nucleosomes and higher-order …

One clear hallmark of mammalian promoters is the presence of CpG islands (CGIs) at more
than two-thirds of genes, whereas TATA boxes are only present at a minority of promoters …

The size of a eukaryotic genome presents a unique challenge to the cell: package and
organize the DNA to fit within the confines of the nucleus while at the same time ensuring …

We have developed a chemical cleavage method that allows precise map** of both single
nucleosomes and linkers genome-wide in budding yeast. We confirm that S. cerevisiae …

The parameters involved in human cytomegalovirus (HCMV) latent infection in CD14 (+) and
CD34 (+) cells remain poorly identified. Using next generation sequencing we deduced the …

The epigenome is established and maintained by the site-specific recruitment of chromatin-
modifying enzymes and their cofactors. Identifying the cis elements that regulate epigenomic …