Lipoprotein lipase (LPL) is a multifunctional enzyme produced by many tissues, including
adipose tissue, cardiac and skeletal muscle, islets, and macrophages. LPL is the rate …

Exchangeable apolipoproteins function in lipid transport as structural components of
lipoprotein particles, cofactors for enzymes and ligands for cell-surface receptors. Recent …

The triglycerides in chylomicrons are hydrolyzed by lipoprotein lipase (LpL) along the
luminal surface of the capillaries. However, the endothelial cell molecule that facilitates …

Atorvastatin ester (Ate) is a structural trim of atorvastatin that can regulate hyperlipidemia.
The purpose of this study was to evaluate the lipid-lowering effect of Ate. Male Sprague …

ApoAV has been discovered recently as a novel modifier of triglyceride (TG) metabolism, but
the pathways involved are currently unknown. To gain insight into the function of apoAV …

Apolipoprotein A5 (APOA5) is associated with differences in triglyceride levels and familial
combined hyperlipidemia. In genetically engineered mice, apoAV plasma levels are …

Background: The recently discovered apolipoprotein A5 (ApoA5) is fast gaining attention as
a key regulator of serum triglyceride concentrations. An ApoA5 mouse knock-out model …

Sepsis and septic shock are important causes of morbidity and lethality in noncoronary
intensive care units. Circulating levels of high-density lipoproteins (HDLs) are reduced in …

Since its discovery, apolipoprotein AV has been considered to be a potent factor affecting
plasma triglycerides (TG) in humans and mice. Several single nucleotide polymorphisms in …

Objective—Mutations in LPL or APOC2 genes are recognized causes of inherited forms of
severe hypertriglyceridemia. However, some hypertrigliceridemic patients do not have …