Abstract Interleukin10 (IL10) and IL10 receptor (IL10R) deficiencies are monogenic inborn
errors of immunity (IEI) causing early-onset inflammatory bowel diseases (IBD). In this report …

The SARS-CoV-2 virus has caused a worldwide COVID-19 pandemic. In less than a year
and a half, more than 200 million people have been infected and more than four million …

Transcriptome-wide association studies (TWAS) are popular approaches to test for
association between imputed gene expression levels and traits of interest. Here, we propose …

The new coronavirus infection represents a serious threat to global health and economies.
In this sense, it is paramount to know the nutritional factors that may be related to the …

The COVID-19 pandemic has presented an unprecedented challenge to the healthcare
system. Identifying the genomics and clinical biomarkers for effective patient stratification …

Abstract We present ANANASTRA, https://ananastra. autosome. org, a web server for the
identification and annotation of regulatory single-nucleotide polymorphisms (SNPs) with …

The highly heterogeneous symptomatology and unpredictable progress of COVID‑19
triggered unprecedented intensive biomedical research and a number of clinical research …

Objectives Our objective was to examine coronary endothelial and myocardial programming
in patients with severe COVID-19 utilizing digital spatial transcriptomics. Background Severe …

We developed a computational framework that integrates Genome-Wide Association
Studies (GWAS) and post-GWAS analyses, designed to facilitate drug repurposing for …

In this study, we use integrated transcriptomic datasets from the GEO repository with the
purpose of investigating immune dysregulation in COVID-19. Thus, in this context, we …