Advances in the development of new tuberculosis drugs and treatment regimens
Despite the introduction 40 years ago of the inexpensive and effective four-drug (isoniazid,
rifampicin, pyrazinamide and ethambutol) treatment regimen, tuberculosis (TB) continues to …
rifampicin, pyrazinamide and ethambutol) treatment regimen, tuberculosis (TB) continues to …
[HTML][HTML] NTM drug discovery: status, gaps and the way forward
Highlights•Incidence of lung disease caused by non-TB mycobacteria (NTM) is
increasing.•Current treatments are ineffective.•There is an urgent need to establish a drug …
increasing.•Current treatments are ineffective.•There is an urgent need to establish a drug …
Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing
Over 30% of the world's population is infected with Mycobacterium tuberculosis (Mtb), yet
only∼ 5–10% will develop clinical disease. Despite considerable effort, researchers …
only∼ 5–10% will develop clinical disease. Despite considerable effort, researchers …
[PDF][PDF] High priority target product profiles for new tuberculosis diagnostics: report of a consensus meeting, 28-29 April 2014, Geneva, Switzerland
World Health Organization - 2014 - apps.who.int
Executive summary Globally, one third of all tuberculosis (TB) cases are not notified, and
many patients' samples do not undergo drug-susceptibility testing (DST). To achieve the …
many patients' samples do not undergo drug-susceptibility testing (DST). To achieve the …
In search of a new paradigm for protective immunity to TB
Clinical trials of vaccines against Mycobacterium tuberculosis are well under way and
results are starting to come in. Some of these results are not so encouraging, as exemplified …
results are starting to come in. Some of these results are not so encouraging, as exemplified …
A systematic review of biomarkers to detect active tuberculosis
Millions of cases of tuberculosis (TB) go undiagnosed each year. Better diagnostic tools are
urgently needed. Biomarker-based or multiple marker biosignature-based tests, ideally …
urgently needed. Biomarker-based or multiple marker biosignature-based tests, ideally …
Variability in tuberculosis granuloma T cell responses exists, but a balance of pro-and anti-inflammatory cytokines is associated with sterilization
Lung granulomas are the pathologic hallmark of tuberculosis (TB). T cells are a major
cellular component of TB lung granulomas and are known to play an important role in …
cellular component of TB lung granulomas and are known to play an important role in …
New antituberculosis drugs, regimens, and adjunct therapies: needs, advances, and future prospects
About 1· 3 million people died of tuberculosis in 2012, despite availability of effective drug
treatment. Barriers to improvements in outcomes include long treatment duration (resulting …
treatment. Barriers to improvements in outcomes include long treatment duration (resulting …
Single-cell transcriptomics of blood reveals a natural killer cell subset depletion in tuberculosis
Background Tuberculosis (TB) continues to be a critical global health problem, which killed
millions of lives each year. Certain circulating cell subsets are thought to differentially …
millions of lives each year. Certain circulating cell subsets are thought to differentially …
The mycobacterial cell envelope—lipids
M Jackson - Cold Spring Harbor perspectives in …, 2014 - perspectivesinmedicine.cshlp.org
Mycobacterium tuberculosis (Mtb) lipids are indelibly imprinted in just about every key
aspect of tuberculosis (TB) basic and translational research. Although the interest in these …
aspect of tuberculosis (TB) basic and translational research. Although the interest in these …