Purpose An ever-growing number of predictive models used to inform clinical decision
making have included quantitative, computer-extracted imaging biomarkers, or “radiomic …

Radiomics is an emerging field in quantitative imaging that uses advanced imaging features
to objectively and quantitatively describe tumour phenotypes. Radiomic features have …

The process of develo** predictive models includes many stages. Most resources focus
on the modeling algorithms but neglect other critical aspects of the modeling process. This …

Prediction models in health care use predictors to estimate for an individual the probability
that a condition or disease is already present (diagnostic model) or will occur in the future …

Here, we summarise the unresolved debate about p value and its dichotomisation. We
present the statement of the American Statistical Association against the misuse of statistical …

Abstract" Optimal cutpoints" for binary classification tasks are often established by testing
which cutpoint yields the best discrimination, for example the Youden index, in a specific …

Summary Background Tyrosine kinase inhibitors (TKIs) have improved the survival of
patients with chronic myeloid leukaemia. Many patients have deep molecular responses, a …

Abstract The Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK)
were developed to address widespread deficiencies in the reporting of such studies. The …

The TRIPOD (Transparent Reporting of a multivariable prediction model for Individual
Prognosis Or Diagnosis) Statement includes a 22-item checklist, which aims to improve the …

Series Editors' Note We are pleased to add this typescript to the Bone Marrow
Transplantation Statistics Series. We realize the term cubic splines may be a bit off-putting to …