Genetic drugs based on nucleic acid biomolecules are a rapidly emerging class of
medicines that directly reprogramme the central dogma of biology to prevent and treat …

Decades have passed since the first nanoparticles-base medicine was approved for human
cancer treatment, and the research and development of nanoparticles for drug delivery are …

Messenger RNA (mRNA) has received great attention in the prevention and treatment of
various diseases due to the success of coronavirus disease 2019 (COVID‐19) mRNA …

Fully targeted mRNA therapeutics necessitate simultaneous organ-specific accumulation
and effective translation. Despite some progress, delivery systems are still unable to fully …

In recent years, nanoparticles have evolved to a clinical modality to deliver diverse nucleic
acids. Rising interest in nanomedicines comes from proven safety and efficacy profiles …

The concept of using mRNA to produce its own medicine in situ in the body makes it an ideal
drug candidate, holding great potential to revolutionize the way we approach medicine. The …

Among the few available mRNA delivery vehicles, lipid nanoparticles (LNPs) are the most
clinically advanced but they require cumbersome four components and suffer from …

It is urgent to develop more effective mRNA vaccines against the emerging severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) variants owing to the immune escape …

Nanotechnology has shown tremendous success in the drug delivery field for more effective
and safer therapy, and has recently enabled the clinical approval of RNA medicine, a new …

Lipid nanoparticles (LNPs) represent the most clinically advanced nonviral mRNA delivery
vehicles; however, the full potential of the LNP platform is greatly hampered by inadequate …