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Cooperation between SIX1 and DHX9 transcriptionally regulates integrin-focal adhesion signaling mediated metastasis and sunitinib resistance in KIRC
High invasive capacity and acquired tyrosine kinase inhibitors (TKI) resistance of kidney
renal clear cell carcinoma (KIRC) cells remain obstacles to prolonging the survival time of …
renal clear cell carcinoma (KIRC) cells remain obstacles to prolonging the survival time of …
Jagged1 intracellular domain/SMAD3 complex transcriptionally regulates TWIST1 to drive glioma invasion
Abstract Jagged1 (JAG1) is a Notch ligand that correlates with tumor progression. Not
limited to its function as a ligand, JAG1 can be cleaved, and its intracellular domain …
limited to its function as a ligand, JAG1 can be cleaved, and its intracellular domain …
[HTML][HTML] Functional mechanisms and potential therapeutic strategies for lactylation in liver disease
R Xu, Y Hao, Y Liu, B Ji, W Tian, W Zhang - Life Sciences, 2025 - Elsevier
Lactylation, a novel form of lactate-mediated protein post-translational modification (PTM),
has been identified as a crucial regulator of gene expression and protein function through …
has been identified as a crucial regulator of gene expression and protein function through …
Sulindac sulfide as a non-immune suppressive γ-secretase modulator to target triple-negative breast cancer
Introduction Triple-negative breast cancer (TNBC) comprises a heterogeneous group of
clinically aggressive tumors with high risk of recurrence and metastasis. Current …
clinically aggressive tumors with high risk of recurrence and metastasis. Current …
MOGS promotes stemness acquisition and invasion via enhancing NOTCH1-glycosylation dependent NOTCH pathway in colorectal cancer
S Zhou, H Huang, Z Zheng, K Zheng… - American Journal of …, 2023 - pmc.ncbi.nlm.nih.gov
Colorectal cancer (CRC) ranks as the third most prevalent cancer globally, and about half of
CRC patients eventually succumb to tumor metastasis. Despite this, treatment options for …
CRC patients eventually succumb to tumor metastasis. Despite this, treatment options for …
Cancer-wide in silico analyses using differentially expressed genes demonstrate the functions and clinical relevance of JAG, DLL, and NOTCH
Notch ligands [jagged (JAG) and, delta-like (DLL) families] and receptors [NOTCH family]
are key regulators of Notch signaling. NOTCH signaling contributes to vascular …
are key regulators of Notch signaling. NOTCH signaling contributes to vascular …
[HTML][HTML] Smad2 Cooperating with TGIF2 Contributes to EMT and Cancer Stem Cells Properties in Pancreatic Cancer via Co-Targeting SOX2
F Zu, CP Chen, Q Geng, H Li, B Chan… - International …, 2025 - pmc.ncbi.nlm.nih.gov
The underlying mechanisms between cancer stem cells (CSC) and epithelial-mesenchymal
transition (EMT) in pancreatic cancer (PC) remain unclear. In this study, we identified TGIF2 …
transition (EMT) in pancreatic cancer (PC) remain unclear. In this study, we identified TGIF2 …
[HTML][HTML] Annexin A2 Stabilizes Oncogenic JAG1 Intracellular Domain by Inhibiting Proteasomal Degradation in Glioblastoma Cells
Glioblastoma (GBM) is the most lethal brain cancer, causing inevitable deaths of patients
owing to frequent relapses of cancer stem cells (CSCs). The significance of the NOTCH …
owing to frequent relapses of cancer stem cells (CSCs). The significance of the NOTCH …
Aberrant expression of PELI1 caused by Jagged1 accelerates the malignant phenotype of pancreatic cancer
W Zhou, Y Hu, B Wang, L Yuan, J Ma, X Meng - Cellular Signalling, 2023 - Elsevier
Pancreatic cancer is one of the most aggressive cancers. PELI1 has been reported to
promote cell survival and proliferation in multiple cancers. As of now, the role of PELI1 in …
promote cell survival and proliferation in multiple cancers. As of now, the role of PELI1 in …
(E)‐SIS3 suppressed osteosarcoma progression via promoting cell apoptosis, arresting cell cycle, and regulating the tumor immune microenvironment
Z Huang, C Zhang, K Zhu, J Hu, E Xu… - Drug Development …, 2023 - Wiley Online Library
Osteosarcoma is a prevalent malignant bone tumor with a poor prognosis. Mothers against
decapentaplegic homolog 3 (Smad3) present as a therapeutic target in antitumor treatment …
decapentaplegic homolog 3 (Smad3) present as a therapeutic target in antitumor treatment …