The aetiology and molecular landscape of insulin resistance

DE James, J Stöckli, MJ Birnbaum - Nature Reviews Molecular Cell …, 2021 - nature.com
Insulin resistance, defined as a defect in insulin-mediated control of glucose metabolism in
tissues—prominently in muscle, fat and liver—is one of the earliest manifestations of a …

Pathophysiological roles of chronic low‐grade inflammation mediators in polycystic ovary syndrome

M Rostamtabar, S Esmaeilzadeh… - Journal of cellular …, 2021 - Wiley Online Library
Polycystic ovary syndrome (PCOS) is the most common hormonal imbalance disease in
reproductive‐aged women. Its basic characteristics are ovulatory dysfunction and ovarian …

Prepregnancy BMI and the risk of gestational diabetes: a systematic review of the literature with meta‐analysis

MR Torloni, AP Betrán, BL Horta… - Obesity …, 2009 - Wiley Online Library
The objective of this study is to assess and quantify the risk for gestational diabetes mellitus
(GDM) according to prepregnancy maternal body mass index (BMI). The design is a …

Maternal body mass index and risk of birth and maternal health outcomes in low‐and middle‐income countries: a systematic review and meta‐analysis

MM Rahman, SK Abe, M Kanda, S Narita… - Obesity …, 2015 - Wiley Online Library
We conducted a systematic review and meta‐analysis of population‐based cohort studies of
maternal body mass index (BMI) and risk of adverse birth and health outcomes in low‐and …

Adiposity and insulin resistance in humans: the role of the different tissue and cellular lipid depots

S Hocking, D Samocha-Bonet, KL Milner… - Endocrine …, 2013 - academic.oup.com
Human adiposity has long been associated with insulin resistance and increased
cardiovascular risk, and abdominal adiposity is considered particularly adverse. Intra …

Etiology, treatment, and prevention of obesity in childhood and adolescence: A decade in review

D Spruijt‐Metz - Journal of research on Adolescence, 2011 - Wiley Online Library
Childhood obesity has become an epidemic on a worldwide scale. This article gives an
overview of the progress made in childhood and adolescent obesity research in the last …

Predictors of postpartum diabetes in women with gestational diabetes mellitus

K Lobner, A Knopff, A Baumgarten, U Mollenhauer… - Diabetes, 2006 - diabetesjournals.org
The aim of this study was to stratify risk for postpartum diabetes in women who have
gestational diabetes. Women with gestational diabetes were recruited between 1989 and …

Increased activation of nuclear factor κB triggers inflammation and insulin resistance in polycystic ovary syndrome

F González, NS Rote, J Minium… - The Journal of Clinical …, 2006 - academic.oup.com
Context: Insulin resistance and chronic low level inflammation are often present in women
with polycystic ovary syndrome (PCOS). Objective: The purpose of this study was to …

Higher normal fasting plasma glucose is associated with hippocampal atrophy: The PATH Study

N Cherbuin, P Sachdev, KJ Anstey - Neurology, 2012 - neurology.org
Objectives: Substantial evidence showing an association between type 2 diabetes (T2D)
and cerebral atrophy, cognitive impairment, and dementia is accumulating. However …

Adiponectin: an adipokine with protective features against metabolic syndrome

M Esfahani, A Movahedian, M Baranchi… - Iranian journal of …, 2015 - pmc.ncbi.nlm.nih.gov
Metabolic syndrome (MetS) as a collection of obesity-associated disorders is associated
with inflammation, oxidative stress, pro-thrombotic state, elevated risk of develo** …