Angiogenesis is a requirement for tumor growth and metastasis. The angiogenic process
depends on vascular endothelial cell migration and invasion, and is regulated by various …

Molecular radiopharmaceuticals based on bioconjugates of chelators with peptides and
proteins have had significant clinical impact in the diagnosis and treatment of several types …

Following injurious stimuli, quiescent hepatic stellate cells (qHSCs) transdifferentiate into
activated HSCs (aHSCs). aHSCs play pivotal roles in the onset and progression of liver …

99mTc-3PRGD2 is a new SPECT tracer targeting integrin αVβ3 receptor for detecting
tumors, imaging angiogenesis, and evaluating tumor response to therapy. A multicenter …

The integrin family comprises 24 transmembrane receptors, each a heterodimeric
combination of one of 18α and one of 8β subunits. Their main function is to integrate the cell …

Integrin αvβ3 has been proposed as a potential imaging target for radiolabeled RGD
peptides and a molecular marker for the estimation of tumor angiogenesis, yet it has not …

Purpose To evaluate an integrin imaging approach based on single photon emission
computed tomography (SPECT)/computed tomography (CT) by using technetium 99m …

Purpose: Ischemic vascular diseases, including myocardial infarction (MI) and stroke, have
been found to be associated with elevated expression of α v β 3-integrin, which provides a …

The integrin alpha (α) v beta (β) 3 receptor is ubiquitous in malignant tumors and has a
certain level of specificity for tumors. Technetium-99m hydrazinonicotinamide-dimeric cyclic …

Targeting overexpressed receptors on the cancer cells with radiolabeled peptides has
become very important in nuclear oncology in the recent years. Peptides are small and have …