The methods of synthesis, modification, and biological activity of 4-quinolones

AA Boteva, OP Krasnykh - Chemistry of heterocyclic compounds, 2009 - Springer
THE METHODS OF SYNTHESIS, MODIFICATION, AND BIOLOGICAL ACTIVITY OF 4-QUINOLONES
(REVIEW) Page 1 Chemistry of Heterocyclic Compounds, Vol. 45, No. 7, 2009 THE …

Recent advances in one-pot modular synthesis of 2-Quinolones

WP Hong, I Shin, HN Lim - Molecules, 2020 - mdpi.com
It is known that 2-quinolones are broadly applicable chemical structures in medicinal and
agrochemical research as well as various functional materials. A number of current …

[KNIHA][B] The alkaloids: chemistry and biology

GA Cordell - 2008 - books.google.com
This series is world-renowned as the leading compilation of current reviews of this vast field.
Internationally acclaimed for more than 40 years, The Alkaloids: Chemistry and Biology …

Sequential Cu-Catalyzed Amidation-Base-Mediated Camps Cyclization:  A Two-Step Synthesis of 2-Aryl-4-quinolones from o-Halophenones

CP Jones, KW Anderson… - The Journal of organic …, 2007 - ACS Publications
A direct two-step method for the preparation of 2-aryl-and 2-vinyl-4-quinolones that utilizes a
copper-catalyzed amidation of o-halophenones followed by a base-promoted Camps …

Endochin Optimization: Structure−Activity and Structure−Property Relationship Studies of 3-Substituted 2-Methyl-4(1H)-quinolones with Antimalarial Activity

RM Cross, A Monastyrskyi, TS Mutka… - Journal of medicinal …, 2010 - ACS Publications
Since the 1940s endochin and analogues thereof were known to be causal prophylactic and
potent erythrocytic stage agents in avian models. Preliminary screening in a current in vitro …

A mild, one-pot synthesis of 4-quinolones via sequential Pd-catalyzed amidation and base-promoted cyclization

J Huang, Y Chen, AO King, M Dilmeghani… - Organic …, 2008 - ACS Publications
A mild, one-pot synthesis of 4-quinolones is described. Under the optimal conditions, a
variety of 2-substituted 4-quinolones were synthesized via sequential palladium-catalyzed …

Accelerated dereplication of crude extracts using HPLC–PDA–MS–SPE–NMR: Quinolinone alkaloids of Haplophyllum acutifolium

D Staerk, JR Kesting, M Sairafianpour, M Witt, J Asili… - Phytochemistry, 2009 - Elsevier
Direct hyphenation of analytical-scale high-performance liquid chromatography, photo-
diode array detection, mass spectrometry, solid-phase extraction and nuclear magnetic …

Recent Advances in the Synthesis of N-Containing Heteroaromatics via Heterogeneously Transition Metal Catalysed Cross-Coupling Reactions

L Djakovitch, N Batail, M Genelot - Molecules, 2011 - mdpi.com
N-containing heteroaromatics are important substructures found in numerous natural or
synthetic alkaloids. The diversity of the structures encountered, as well as their biological …

Evaluation of synthetic acridones and 4-quinolinones as potent inhibitors of cathepsins L and V

EF Marques, MA Bueno, PD Duarte, LRSP Silva… - European journal of …, 2012 - Elsevier
Cathepsins, also known as lysosomal cysteine peptidases, are members of the papain-like
peptidase family, involved in different physiological processes. In addition, cathepsins are …

Mild, rapid and efficient metal-free synthesis of 2-aryl-4-aryloxyquinolines via direct Csp2O bond formation by using diaryliodonium salts

PD Nahide, CR Solorio-Alvarado - Tetrahedron Letters, 2017 - Elsevier
An efficient ligand-and transition metal-free procedure for the direct C sp 2 single bond O
bond formation for the arylation of 2-aryl-4-quinolones was developed. The synthesis of the …