Polymyositis and dermatomyositis are inflammatory myopathies that differ in their clinical
features, histopathology, response to treatment, and prognosis. Although their clinical …

Muscles operate eccentrically to either dissipate energy for decelerating the body or to store
elastic recoil energy in preparation for a shortening (concentric) contraction. The muscle …

Pum** of the heart is powered by filaments of the motor protein myosin that pull on actin
filaments to generate cardiac contraction. In addition to myosin, the filaments contain cardiac …

Cell Movements vividly describes how complex movements can arise from the properties
and behaviors of biological molecules. This second edition is updated throughout with …

Titin is a giant vertebrate striated muscle protein with critical importance for myofibril
elasticity and structural integrity. We show here that the complete sequence of the human …

Congestive heart failure (CHF) can result from various disease states with inadequate
cardiac output. CHF due to dilated cardiomyopathy (DCM) is a familial disease in 20–30% of …

The sarcomere contains, in addition to thin and thick filaments, a filament composed of the
giant protein titin (also known as connectin). Titin molecules anchor in the Z-disc and extend …

When the force applied to a muscle exceeds the force produced by the muscle it will
lengthen, absorbing mechanical energy. These eccentric contractions, which result in both …

The E3 ubiquitin ligase MuRF1/TRIM63 was identified 20 years ago and suspected to play
important roles during skeletal muscle atrophy. Since then, numerous studies have been …

Extension of the I-band segment of titin gives rise to part of the diastolic force of cardiac
muscle. Previous studies of human cardiac titin transcripts suggested a series of differential …