I. Introduction Hormonal therapy for breast carcinoma began with the observation by George
Beatson (1) in 1898 that bilateral oophorectomy caused tumor regression in selected …

Ki67 is a proliferation marker. It has been proposed as a useful clinical marker for breast
cancer subtype classification, prognosis, and prediction of therapeutic response. But the …

Purpose: No consensus exists on therapy of elderly cancer patients. Treatments are
influenced by unclear standards and are usually less aggressive. This study aims to …

Background Neoadjuvant chemotherapy improves overall survival and renders possible
breast-conserving treatment in locally advanced breast cancer. It was necessary for this …

Synopsis Tamoxifen, a non-steroidal antioestrogen, represents a significant advance in
treatment of female breast cancer. In trials of tamoxifen as postsurgical adjuvant treatment of …

Three hundred and eighty-one women with operable breast cancer aged over 70 years
were randomly allocated to 40 mg tamoxifen daily and optimal surgery or to tamoxifen alone …

Summary Background In the Netherlands, 45% of all cancer cases occur in men and women
aged 70 years and older. Since the population is ageing and cancer incidence rises with …

Background Elderly population is on rise. It is an ethical dilemma how aggressive one
should be when it comes to treat cancer in elderly. Presumed fear of increased …

PURPOSE: To evaluate the long-term cause-specific survival (CSS), locoregional
recurrence-free survival (LRFS), and metastases-free survival (MFS) in elderly breast cancer …

BACKGROUND: Recent studies have noted that a large fraction of elderly patients do not
receive conventional treatment for breast cancer. The consequences of undertreatment of …