Lights, fiber, action! A primer on in vivo fiber photometry

EH Simpson, T Akam, T Patriarchi, M Blanco-Pozo… - Neuron, 2024‏ - cell.com
Fiber photometry is a key technique for characterizing brain-behavior relationships in vivo.
Initially, it was primarily used to report calcium dynamics as a proxy for neural activity via …

Detection, processing and reinforcement of social cues: regulation by the oxytocin system

R Menon, ID Neumann - Nature Reviews Neuroscience, 2023‏ - nature.com
Many social behaviours are evolutionarily conserved and are essential for the healthy
development of an individual. The neuropeptide oxytocin (OXT) is crucial for the fine-tuned …

A tool kit of highly selective and sensitive genetically encoded neuropeptide sensors

H Wang, T Qian, Y Zhao, Y Zhuo, C Wu, T Osakada… - Science, 2023‏ - science.org
Neuropeptides are key signaling molecules in the endocrine and nervous systems that
regulate many critical physiological processes. Understanding the functions of …

Interaction of acetylcholine and oxytocin neuromodulation in the hippocampus

Y Zhang, M Karadas, JJ Liu, X Gu, M Vöröslakos, Y Li… - Neuron, 2024‏ - cell.com
A postulated role of subcortical neuromodulators is to control brain states. Mechanisms by
which different neuromodulators compete or cooperate at various temporal scales remain an …

Unlocking opioid neuropeptide dynamics with genetically encoded biosensors

C Dong, R Gowrishankar, Y **, XJ He, A Gupta… - Nature …, 2024‏ - nature.com
Neuropeptides are ubiquitous in the nervous system. Research into neuropeptides has
been limited by a lack of experimental tools that allow for the precise dissection of their …

Genetically encoded sensors for the in vivo detection of neurochemical dynamics

Y Yang, B Li, Y Li - Annual Review of Analytical Chemistry, 2024‏ - annualreviews.org
The ability to measure dynamic changes in neurochemicals with high spatiotemporal
resolution is essential for understanding the diverse range of functions mediated by the …

Presynaptic sensor and silencer of peptidergic transmission reveal neuropeptides as primary transmitters in pontine fear circuit

DI Kim, S Park, S Park, M Ye, JY Chen, SJ Kang… - Cell, 2024‏ - cell.com
Neurons produce and release neuropeptides to communicate with one another. Despite
their importance in brain function, circuit-based mechanisms of peptidergic transmission are …

Stochastic neuropeptide signals compete to calibrate the rate of satiation

SX Zhang, A Kim, JC Madara, PK Zhu, LF Christenson… - Nature, 2024‏ - nature.com
Neuropeptides have important roles in neural plasticity, spiking and behaviour. Yet, many
fundamental questions remain regarding their spatiotemporal transmission, integration and …

Neuromodulator and neuropeptide sensors and probes for precise circuit interrogation in vivo

J Muir, M Anguiano, CK Kim - Science, 2024‏ - science.org
To determine how neuronal circuits encode and drive behavior, it is often necessary to
measure and manipulate different aspects of neurochemical signaling in awake animals …

Erectile dysfunction: treatments, advances and new therapeutic strategies

A Argiolas, FM Argiolas, G Argiolas, MR Melis - Brain sciences, 2023‏ - mdpi.com
Erectile dysfunction (ED) is the inability to get and maintain an adequate penile erection for
satisfactory sexual intercourse. Due to its negative impacts on men's life quality and increase …