4′-Fluoro-nucleosides and nucleotides: from nucleocidin to an emerging class of therapeutics
PT Lowe, D O'Hagan - Chemical Society Reviews, 2023 - pubs.rsc.org
The history and development of 4′-fluoro-nucleosides is discussed in this review. This is a
class of nucleosides which have their origin in the discovery of the rare fluorine containing …
class of nucleosides which have their origin in the discovery of the rare fluorine containing …
Purine nucleoside antibiotics: recent synthetic advances harnessing chemistry and biology
Covering: 2019 to 2023Nucleoside analogues represent one of the most important classes
of small molecule pharmaceuticals and their therapeutic development is successfully …
of small molecule pharmaceuticals and their therapeutic development is successfully …
Reasons why life on Earth rarely makes fluorine-containing compounds and their implications for the search for life beyond Earth
JJ Petkowski, S Seager, W Bains - Scientific Reports, 2024 - nature.com
Life on Earth is known to rarely make fluorinated carbon compounds, as compared to other
halocarbons. We quantify this rarity, based on our exhaustive natural products database …
halocarbons. We quantify this rarity, based on our exhaustive natural products database …
Synthesis of Nicotinamide Mononucleotide from Xylose via Coupling Engineered Escherichia coli and a Biocatalytic Cascade
U Ngivprom, P Lasin, P Khunnonkwao… - …, 2022 - Wiley Online Library
Abstract β‐Nicotinamide mononucleotide (NMN) has recently gained attention for a
nutritional supplement because it is an intermediate in the biosynthesis of nicotinamide …
nutritional supplement because it is an intermediate in the biosynthesis of nicotinamide …
Streptomyces aureorectus DSM 41692 and Streptomyces virens DSM 41465 are producers of the antibiotic nucleocidin and 4′-fluoroadenosine is identified as a co …
Y Chen, Q Zhang, X Feng, M Wojnowska… - Organic & Biomolecular …, 2021 - pubs.rsc.org
Genome homology and the presence of a putative biosynthetic gene cluster identified
Streptomyces aureorectus DSM 41692 and Streptomyces virens DSM 41465 as candidate …
Streptomyces aureorectus DSM 41692 and Streptomyces virens DSM 41465 as candidate …
Identification of genes essential for sulfamate and fluorine incorporation during nucleocidin biosynthesis
Nucleocidin is an adenosine derivative containing 4'‐fluoro and 5'‐O‐sulfamoyl substituents.
In this study, nucleocidin biosynthesis is examined in two newly discovered producers …
In this study, nucleocidin biosynthesis is examined in two newly discovered producers …
Identification of Genes Essential for Fluorination and Sulfamylation within the Nucleocidin Gene Clusters of Streptomyces calvus and Streptomyces virens
The gene cluster in Streptomyces calvus associated with the biosynthesis of the fluoro‐and
sulfamyl‐metabolite nucleocidin was interrogated by systematic gene knockouts. Out of the …
sulfamyl‐metabolite nucleocidin was interrogated by systematic gene knockouts. Out of the …
Recent advances in fluorinated products biosynthesis
S Shi, J Tian, Y Luo - Bioresource Technology Reports, 2022 - Elsevier
The introduction of fluorine to the drug molecules endows the compounds with better
metabolic stability and bioavailability. However, naturally occurring fluorides are rare and …
metabolic stability and bioavailability. However, naturally occurring fluorides are rare and …
3′-O-β-Glucosyl-4′,5′-didehydro-5′-deoxyadenosine Is a Natural Product of the Nucleocidin Producers Streptomyces virens and Streptomyces calvus
3′-O-β-Glucosyl-4′, 5′-didehydro-5′-deoxyadenosine 13 is identified as a natural
product of Streptomyces calvus and Streptomyces virens. It is also generated in vitro by …
product of Streptomyces calvus and Streptomyces virens. It is also generated in vitro by …
[PDF][PDF] Natural Product Reports
A Kurreck, GJ Miller - Nat. Prod. Rep, 2024 - depositonce.tu-berlin.de
Nucleoside analogues represent one of the most important classes of small molecule
pharmaceuticals and their therapeutic development is successfully established within …
pharmaceuticals and their therapeutic development is successfully established within …