The history and development of 4′-fluoro-nucleosides is discussed in this review. This is a
class of nucleosides which have their origin in the discovery of the rare fluorine containing …

Covering: 2019 to 2023 Nucleoside analogues represent one of the most important classes
of small molecule pharmaceuticals and their therapeutic development is successfully …

Life on Earth is known to rarely make fluorinated carbon compounds, as compared to other
halocarbons. We quantify this rarity, based on our exhaustive natural products database …

Abstract β‐Nicotinamide mononucleotide (NMN) has recently gained attention for a
nutritional supplement because it is an intermediate in the biosynthesis of nicotinamide …

Nucleocidin is an adenosine derivative containing 4'‐fluoro and 5'‐O‐sulfamoyl substituents.
In this study, nucleocidin biosynthesis is examined in two newly discovered producers …

The gene cluster in Streptomyces calvus associated with the biosynthesis of the fluoro‐and
sulfamyl‐metabolite nucleocidin was interrogated by systematic gene knockouts. Out of the …

Genome homology and the presence of a putative biosynthetic gene cluster identified
Streptomyces aureorectus DSM 41692 and Streptomyces virens DSM 41465 as candidate …

3′-O-β-Glucosyl-4′, 5′-didehydro-5′-deoxyadenosine 13 is identified as a natural
product of Streptomyces calvus and Streptomyces virens. It is also generated in vitro by …

Comprehensive Summary HpnG plays a crucial role in the production of ribosylhopane, a
key intermediate in the biosynthesis of bacteriohopanepolyol. Despite early extensive …

The introduction of fluorine to the drug molecules endows the compounds with better
metabolic stability and bioavailability. However, naturally occurring fluorides are rare and …