The Wnt signal transduction pathway has essential roles in the formation of the primary body
axis during development, cellular differentiation and tissue homeostasis. This animal …

Metastasis remains the greatest challenge in the clinical management of cancer. Cell motility
is a fundamental and ancient cellular behaviour that contributes to metastasis and is …

Abstract tRNAscan-SE has been widely used for transfer RNA (tRNA) gene prediction for
over twenty years, developed just as the first genomes were decoded. With the massive …

Assembly-line polyketide synthases (PKSs) are among the most complex protein
machineries known in nature, responsible for the biosynthesis of numerous compounds …

Bacteria influence eukaryotic biology as parasitic, commensal or beneficial symbionts. Aside
from these organismal interactions, bacteria have also been important sources of new …

Cancer cell migration and invasion are integral components of metastatic disease, which is
the major cause of death in cancer patients. Cancer cells can disseminate and migrate via …

Highlights•Biological lignocellulose deconstruction mechanisms are diverse.•They are
widely but sparsely dispersed across the Tree of Life.•Some mechanisms operate at physico …

Lignocellulosic biomass has enormous potential to contribute to worldwide energy,
chemical, and material demands in a renewable, sustainable manner. In the United States …

Genome sequencing enhances our understanding of the biological world by providing
blueprints for the evolutionary and functional diversity that shapes the biosphere. However …

An unexpectedly large fraction of genes in metazoans (human, mouse, zebrafish, worm, fruit
fly) express high levels of circularized RNAs containing canonical exons. Here we report that …