PIEZO channels respond to piconewton-scale forces to mediate critical physiological and
pathophysiological processes,,,–. Detergent-solubilized PIEZO channels form bowl-shaped …

Piezo ion channels are sensors of mechanical forces and mediate a wide range of
physiological mechanotransduction processes. More than a decade of intense research has …

Abstract Purpose of Review: Atherosclerosis is the principal cause of cardiovascular
diseases (CVDs) which are the major cause of death worldwide. Mechanical force plays an …

Two prominent concepts for the sensing of shear stress by endothelium are the PIEZO1
channel as a mediator of mechanically activated calcium ion entry and the PECAM1 cell …

Piezo1 is a bona fide mechanosensitive ion channel ubiquitously expressed in mammalian
cells. The distribution of Piezo1 within a cell is essential for various biological processes …

The demand for a vaccine for coronavirus disease 2019 (COVID-19) highlighted gaps in our
understanding of the requirements for B cell responses to antigens, particularly to …

Piezo1 channels are essential mechanically activated ion channels in vertebrates. Their
selective activation by the synthetic chemical activator Yoda1 opened new avenues to probe …

Mechanosensitive PIEZO channels constitute potential pharmacological targets for multiple
clinical conditions, spurring the search for potent chemical PIEZO modulators. Among them …

Background and Purpose The protein PIEZO1 forms mechanically activated, calcium‐
permeable, non‐selective cation channels in numerous cell types from several species …

PIEZOs are mechanosensitive ion channels that convert force into chemoelectric signals,
and have essential roles in diverse physiological settings. In vitro studies have proposed …