Molecular mechanisms of cell death in neurological diseases
Tightly orchestrated programmed cell death (PCD) signalling events occur during normal
neuronal development in a spatially and temporally restricted manner to establish the neural …
neuronal development in a spatially and temporally restricted manner to establish the neural …
Caspase‐3: structure, function, and biotechnological aspects
Abstract Caspase‐3, a cysteine‐aspartic acid protease, has recently attracted much
attention because of its incredible roles in tissue differentiation, regeneration, and neural …
attention because of its incredible roles in tissue differentiation, regeneration, and neural …
Innate immune cell death in neuroinflammation and Alzheimer's disease
Alzheimer's disease (AD) is a neurodegenerative disorder molecularly characterized by the
formation of amyloid β (Aβ) plaques and type 2 microtubule-associated protein (Tau) …
formation of amyloid β (Aβ) plaques and type 2 microtubule-associated protein (Tau) …
Traumatic brain injury: mechanistic insight on pathophysiology and potential therapeutic targets
Traumatic brain injury (TBI) causes brain damage, which involves primary and secondary
injury mechanisms. Primary injury causes local brain damage, while secondary damage …
injury mechanisms. Primary injury causes local brain damage, while secondary damage …
The independence of and associations among apoptosis, autophagy, and necrosis
Cell death is an essential biological process for physiological growth and development.
Three classical forms of cell death—apoptosis, autophagy, and necrosis—display distinct …
Three classical forms of cell death—apoptosis, autophagy, and necrosis—display distinct …
[HTML][HTML] Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease
Inflammation occurs as a result of exposure of tissues and organs to harmful stimuli such as
microbial pathogens, irritants, or toxic cellular components. The primary physical …
microbial pathogens, irritants, or toxic cellular components. The primary physical …
[HTML][HTML] The microbiome: a key regulator of stress and neuroinflammation
There is a growing emphasis on the relationship between the complexity and diversity of the
microorganisms that inhabit our gut (human gastrointestinal microbiota) and health/disease …
microorganisms that inhabit our gut (human gastrointestinal microbiota) and health/disease …
Revisiting traumatic brain injury: from molecular mechanisms to therapeutic interventions
Studying the complex molecular mechanisms involved in traumatic brain injury (TBI) is
crucial for develo** new therapies for TBI. Current treatments for TBI are primarily focused …
crucial for develo** new therapies for TBI. Current treatments for TBI are primarily focused …
[HTML][HTML] Autophagy and apoptosis dysfunction in neurodegenerative disorders
Autophagy and apoptosis are basic physiologic processes contributing to the maintenance
of cellular homeostasis. Autophagy encompasses pathways that target long-lived cytosolic …
of cellular homeostasis. Autophagy encompasses pathways that target long-lived cytosolic …
Post-operative cognitive dysfunction: an exploration of the inflammatory hypothesis and novel therapies
Abstract Post-Operative Cognitive Dysfunction (POCD) is a highly prevalent condition with
significant clinical, social and financial impacts for patients and their communities. The …
significant clinical, social and financial impacts for patients and their communities. The …