The centriole is an ancient microtubule-based organelle with a conserved nine-fold
symmetry. Centrioles form the core of centrosomes, which organize the interphase …

Over the past several decades, numerous studies have greatly expanded our knowledge
about how microtubule organization and dynamics are controlled in cultured cells in vitro …

Meiotic spindle assembly ensures proper chromosome segregation in oocytes. However,
the mechanisms behind spindle assembly in human oocytes remain largely unknown. We …

Cells compartmentalize biochemical reactions using organelles. Organelles can be either
membrane-bound compartments or supramolecular assemblies of protein and ribonucleic …

Mitosis is controlled by reversible protein phosphorylation involving specific kinases and
phosphatases. A handful of major mitotic protein kinases, such as the cyclin B–CDK1 …

Sexual reproduction relies on the fusion of paternal and maternal haploid gametes—the
sperm and the extremely large oocyte, respectively—forming a new diploid organism …

Primary cilia organize Hedgehog signaling and shape embryonic development, and their
dysregulation is the unifying cause of ciliopathies. We conducted a functional genomic …

Fertilizable eggs develop from diploid precursor cells termed oocytes. Once every menstrual
cycle, an oocyte matures into a fertilizable egg in the ovary. To this end, the oocyte …

Cortical projection neurons polarize and form an axon while migrating radially. Even though
these dynamic processes are closely interwoven, they are regulated separately—the …

The centriole organelle consists of microtubules (MTs) that exhibit a striking 9-fold radial
symmetry. Centrioles play fundamental roles across eukaryotes, notably in cell signaling …