Extensive studies on HIV-1 have led to the discovery of a variety of structurally and
functionally diverse innate defense factors that target various steps of the retroviral …

Antiretroviral therapy (ART) induces persistent suppression of HIV-1 replication and gradual
recovery of T-cell counts, and consequently, morbidity and mortality from HIV-related …

The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative
agent of coronavirus disease 2019 (COVID-19), was declared a pandemic infection in March …

ABSTRACT HIV-1 must overcome multiple innate antiviral mechanisms to replicate in CD4+
T lymphocytes and macrophages. Previous studies have demonstrated that the …

Emerging evidence indicates that HIV-1 hijacks host DNA damage repair (DDR) pathways to
facilitate multiple facets of virus replication. Canonically, HIV-1 engages proviral DDR …

Macrophages are the first line of defence against invading pathogens. They play a crucial
role in immunity but also in regeneration and homeostasis. Their remarkable plasticity in …

Protein serine/threonine phosphatase 2A (PP2A) regulates diverse cellular processes via
the formation of~ 100 heterotrimeric holoenzymes. However, a scarcity of knowledge on …

HIV remains a health challenge worldwide, partly because of the continued development of
resistance to drugs. Therefore, it is urgent to find new HIV inhibitors and targets …

Accessory proteins are a key feature that distinguishes primate immunodeficiency viruses
such as human immunodeficiency virus type I (HIV-1) from other retroviruses. A prime …

Purpose Despite extensive research, HIV-1 remains a global epidemic with variations in
pathogenesis across regions and subtypes. The Viral Infectivity Factor (Vif) protein, which …