Skeletal and extraskeletal actions of vitamin D: current evidence and outstanding questions

R Bouillon, C Marcocci, G Carmeliet, D Bikle… - Endocrine …, 2019 - academic.oup.com
The etiology of endemic rickets was discovered a century ago. Vitamin D is the precursor of
25-hydroxyvitamin D and other metabolites, including 1, 25 (OH) 2D, the ligand for the …

Exploring vitamin D metabolism and function in cancer

SM Jeon, EA Shin - Experimental & molecular medicine, 2018 - nature.com
Vitamin D, traditionally known as an essential nutrient, is a precursor of a potent steroid
hormone that regulates a broad spectrum of physiological processes. In addition to its …

Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects

S Christakos, P Dhawan, A Verstuyf… - Physiological …, 2016 - journals.physiology.org
1, 25-Dihydroxvitamin D3 [1, 25 (OH) 2D3] is the hormonally active form of vitamin D. The
genomic mechanism of 1, 25 (OH) 2D3 action involves the direct binding of the 1, 25 (OH) …

The role of vitamin D in reducing cancer risk and progression

D Feldman, AV Krishnan, S Swami… - Nature reviews …, 2014 - nature.com
Vitamin D is not really a vitamin but the precursor to the potent steroid hormone calcitriol,
which has widespread actions throughout the body. Calcitriol regulates numerous cellular …

The molecular basis for the pharmacokinetics and pharmacodynamics of curcumin and its metabolites in relation to cancer

M Heger, RF van Golen, M Broekgaarden… - Pharmacological …, 2014 - Elsevier
This review addresses the oncopharmacological properties of curcumin at the molecular
level. First, the interactions between curcumin and its molecular targets are addressed on …

Cytochrome P450-mediated metabolism of vitamin D

G Jones, DE Prosser, M Kaufmann - Journal of lipid research, 2014 - ASBMB
The vitamin D signal transduction system involves a series of cytochrome P450-containing
sterol hydroxylases to generate and degrade the active hormone, 1α, 25-dihydroxyvitamin D …

Vitamin D and human health: lessons from vitamin D receptor null mice

R Bouillon, G Carmeliet, L Verlinden… - Endocrine …, 2008 - academic.oup.com
The vitamin D endocrine system is essential for calcium and bone homeostasis. The precise
mode of action and the full spectrum of activities of the vitamin D hormone, 1, 25 …

25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): its important role in the degradation of vitamin D

G Jones, DE Prosser, M Kaufmann - Archives of biochemistry and …, 2012 - Elsevier
CYP24A1 is the cytochrome P450 component of the 25-hydroxyvitamin D3-24-hydroxylase
enzyme that catalyzes the conversion of 25-hydroxyvitamin D3 (25-OH-D3) and 1, 25 …

World Health Organization classification of tumours: Pathology & genetics of tumours of the urinary system and male genital organs

TY Chan - Urology, 2005 - goldjournal.net
This 2004 volume in the World Health Organization series on histologic and genetic ty**
of human tumors covers tumors of the kidney, urinary system, prostate, testis and …

The anti-inflammatory effects of vitamin D in tumorigenesis

W Liu, L Zhang, HJ Xu, Y Li, CM Hu, JY Yang… - International journal of …, 2018 - mdpi.com
In conjunction with the classical functions of regulating intestinal, bone, and kidney calcium
and phosphorus absorption, as well as bone mineralization of vitamin D, the population …