Ubiquitin-like proteins (Ubl's) are conjugated to target proteins or lipids to regulate their
activity, stability, subcellular localization, or macromolecular interactions. Similar to ubiquitin …

The formation of the autophagosome, a landmark event in autophagy, is accomplished by
the concerted actions of Atg proteins. The initial step of starvation-induced autophagy in …

The mitophagy receptor Nix interacts with LC3/GABARAP proteins, targeting mitochondria
into autophagosomes for degradation. Here we present evidence for phosphorylation-driven …

The ULK1 complex initiates autophagosome formation, linking cellular nutrient status to
downstream events in autophagy. Recent work suggests that the ULK1 complex might also …

Autophagy, self-eating, is a pivotal catabolic mechanism that ensures homeostasis and
survival of the cell in the face of stressors as different as starvation, infection, or protein …

Autophagy complements the ubiquitin-proteasome system in mediating protein turnover.
Whereas the proteasome degrades individual proteins modified with ubiquitin chains …

Autophagy is an essential recycling and quality control pathway. Mammalian ATG8 proteins
drive autophagosome formation and selective removal of protein aggregates and organelles …

The endoplasmic reticulum (ER) is a site of protein biogenesis in eukaryotic cells. Perturbing
ER homeostasis activates stress programs collectively called the unfolded protein response …

Autophagy is a common name for a number of catabolic processes, which keep the cellular
homeostasis by removing damaged and dysfunctional intracellular components. Impairment …

Autophagy is an evolutionary conserved, degradative process from single-cell eukaryotes,
such as Saccharomyces cerevisiae, to higher mammals, such as humans. The regulation of …