Superoxide, O2•−, is formed in all living organisms that come in contact with air, and,
depending upon its biological context, it may act as a signaling agent, a toxic species, or a …

Proteins participate in various essential processes in vivo via interactions with other
molecules. Identifying the residues participating in these interactions not only provides …

Illuminating interactions between proteins and small drug molecules is a long-standing
challenge in the field of drug discovery. Despite the importance of understanding these …

OmcZ nanowires produced by Geobacter species have high electron conductivity (> 30 S
cm− 1). Of 111 cytochromes present in G. sulfurreducens, OmcZ is the only known nanowire …

The degree of evolutionary conservation of an amino acid in a protein or a nucleic acid in
DNA/RNA reflects a balance between its natural tendency to mutate and the overall need to …

It is informative to detect highly conserved positions in proteins and nucleic acid
sequence/structure since they are often indicative of structural and/or functional importance …

Muscarinic M1–M5 acetylcholine receptors are G-protein-coupled receptors that regulate
many vital functions of the central and peripheral nervous systems. In particular, the M1 and …

Key amino acid positions that are important for maintaining the 3D structure of a protein
and/or its function (s), eg catalytic activity, binding to ligand, DNA or other proteins, are often …

Estimating the effects of variants found in disease driver genes opens the door to
personalized therapeutic opportunities. Clinical associations and laboratory experiments …

Patterns observed by examining the evolutionary relationships among proteins of common
origin can reveal the structural and functional importance of specific residue positions. In …