Hazardous drinking and alcohol use disorders
Alcohol is one of the most widely consumed psychoactive drugs globally. Hazardous
drinking, defined by quantity and frequency of consumption, is associated with acute and …
drinking, defined by quantity and frequency of consumption, is associated with acute and …
Assessing negative affect in mice during abstinence from alcohol drinking: Limitations and future challenges
Alcohol use disorder (AUD) is frequently comorbid with mood disorders, and these co-
occurring neuropsychiatric disorders contribute to the development and maintenance of …
occurring neuropsychiatric disorders contribute to the development and maintenance of …
Advancements in the alcohol-associated liver disease model
L Zhu, HD Li, JJ Xu, JJ Li, M Cheng, XM Meng… - Biomolecules, 2022 - mdpi.com
Alcohol-associated liver disease (ALD) is an intricate disease that results in a broad
spectrum of liver damage. The presentation of ALD can include simple steatosis …
spectrum of liver damage. The presentation of ALD can include simple steatosis …
Applying the Addictions Neuroclinical Assessment to derive neurofunctional domains in individuals who use methamphetamine
Abstract The Addictions Neuroclinical Assessment (ANA) was proposed as a neuroscience-
informed clinical framework to understand heterogeneity in addiction encompassing …
informed clinical framework to understand heterogeneity in addiction encompassing …
A novel morphine drinking model of opioid dependence in rats
An animal model of voluntary oral morphine consumption would allow for a pre-clinical
evaluation of new treatments aimed at reducing opioid intake in humans. However, the main …
evaluation of new treatments aimed at reducing opioid intake in humans. However, the main …
Species comparison: human and minipig PBMC reactivity under the influence of immunomodulating compounds in vitro
CPS Pernold, E Lagumdzic, M Stadler… - Frontiers in …, 2024 - frontiersin.org
Considering the similarities between swine and humans, it is a logical consequence to use
swine as a translational model in research and drug development, including non-clinical …
swine as a translational model in research and drug development, including non-clinical …
Translational models of addiction phenotypes to advance addiction pharmacotherapy
Alcohol and substance use disorders are heterogeneous conditions with limited effective
treatment options. While there have been prior attempts to classify addiction subtypes, they …
treatment options. While there have been prior attempts to classify addiction subtypes, they …
Mifepristone as a pharmacological intervention for stress‐induced alcohol craving: A human laboratory study
Preclinical and clinical work suggests that mifepristone may be a viable treatment for alcohol
use disorder (AUD). This was a Phase 1/2, outpatient, cross‐over, randomized, double …
use disorder (AUD). This was a Phase 1/2, outpatient, cross‐over, randomized, double …
Novel medications for problematic alcohol use
Alcohol-related harm, a major cause of disease burden globally, affects people along a
spectrum of use. When a harmful pattern of drinking is present in the absence of significant …
spectrum of use. When a harmful pattern of drinking is present in the absence of significant …
Linking ethanol-addictive behaviors with brain catecholamines: Release pattern matters
Using a variety of animal models that simulate key features of the alcohol use disorder
(AUD), remarkable progress has been made in identifying neurochemical targets that may …
(AUD), remarkable progress has been made in identifying neurochemical targets that may …