Colorectal cancer (CRC) is a heterogeneous disease that is caused by the interaction of
genetic and environmental factors. Although it is one of the most common cancers …

Approximately 90% of colorectal cancer cases are sporadic without family history or genetic
predisposition, while in less than 10% a causative genetic event has been identified …

The current understanding of familial colorectal cancer was limited to descriptions of affected
pedigrees until the early 1990s. A series of landscape‐altering discoveries revealed that …

Colorectal cancer (CRC) is one of the leading causes of cancer related mortality worldwide.
Although young-onset CRC raises the possibility of a hereditary component, hereditary CRC …

Familial adenomatous polyposis (FAP) and MUTYH-associated polyposis (MAP) are rare
inherited polyposis syndromes with a high colorectal cancer (CRC) risk. Therefore, frequent …

We studied 2332 individuals with monoallelic mutations in MUTYH among 9504 relatives of
264 colorectal cancer (CRC) cases with a MUTYH mutation. We estimated CRC risks …

Early-onset colorectal cancer (EOCRC), defined as that diagnosed before the age of 50,
accounts for 10–12% of all new colorectal cancer (CRC) diagnoses. Epidemiological data …

Germline mutations in the DNA base excision repair gene MUTYH are known to increase a
carrier's risk of colorectal cancer. However, the risks of other (extracolonic) cancers for …

The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Colorectal provide
recommendations for the management of patients with high-risk syndromes associated with …

Cellular DNA damage caused by reactive oxygen species is repaired by the base excision
repair (BER) pathway which includes the DNA glycosylase MUTYH. Inherited biallelic …