Chalcone derivatives are considered valuable species because they possess a
ketoethylenic moiety, CO–CH═ CH–. Due to the presence of a reactive α, β-unsaturated …

COVID-19, the highly contagious novel disease caused by SARS-CoV-2, has become a
major international concern as it has spread quickly all over the globe. However, scientific …

Chalcones, containing an α, β-unsaturated ketone fragment, are an important
pharmacologically active agents because of their diverse mechanisms. This review provides …

Pyrimidines are aromatic heterocyclic compounds that contain two nitrogen atoms at
positions 1 and 3 of the six-membered ring. Numerous natural and synthetic pyrimidines are …

Infections caused by Gram‐positive and‐negative bacteria are one of the foremost causes of
morbidity and mortality globally. Antibiotics are the mainstay of therapy for bacterial …

Exaggerated inflammatory responses may cause serious and debilitating diseases such as
acute lung injury and rheumatoid arthritis. Two series of chalcone derivatives were prepared …

Synthesis of some new heterocyclic ring systems incorporated pyrimidine and pyridine
moieties starting from 1-(furan-2-yl)-3-(thiophen-2-yl) chalcone was achieved. The structure …

There is no doubt that significant progress has been made in tumor therapy in the past
decades. However, the discovery of new molecules with potential antitumor properties still …

Edema is one of the obvious indicators of inflammation and a crucial factor to take into
account when assessing a substance's capacity to reduce inflammation. We aimed to …

Abstract A new series of 1, 2, 3-triazole-chalcone hybrids has been synthesized and
screened in vitro against a panel of 60 human cancer cell lines according to NCI (USA) …