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Systems pharmacology: defining the interactions of drug combinations
JGC Van Hasselt, R Iyengar - Annual review of pharmacology …, 2019 - annualreviews.org
The majority of diseases are associated with alterations in multiple molecular pathways and
complex interactions at the cellular and organ levels. Single-target monotherapies therefore …
complex interactions at the cellular and organ levels. Single-target monotherapies therefore …
Microfluidics as a strategic player to decipher single-cell omics?
Most cell studies are performed at a population level, relying on the assumption of a normal
distribution of the function and fate of a cell among a population. However, technologies …
distribution of the function and fate of a cell among a population. However, technologies …
Logic modeling in quantitative systems pharmacology
P Traynard, L Tobalina, F Eduati… - CPT …, 2017 - Wiley Online Library
Here we present logic modeling as an approach to understand deregulation of signal
transduction in disease and to characterize a drug's mode of action. We discuss how to build …
transduction in disease and to characterize a drug's mode of action. We discuss how to build …