Reperfusion injury, the paradoxical tissue response that is manifested by blood flow-
deprived and oxygen-starved organs following the restoration of blood flow and tissue …

Redox-dependent processes influence most cellular functions, such as differentiation,
proliferation, and apoptosis. Mitochondria are at the center of these processes, as …

Nitric oxide (NO) is one of the critical components of the vasculature, regulating key
signaling pathways in health. In macrovessels, NO functions to suppress cell inflammation …

Mitochondrially generated reactive oxygen species are involved in a myriad of signaling and
damaging pathways in different tissues. In addition, mitochondria are an important target of …

Myocardial ischemia-reperfusion injury is an important cause of impaired heart function in
the early postoperative period subsequent to cardiac surgery. Reactive oxygen species …

Providing a comprehensive review of reactions of oxidation for different classes of organic
compounds and polymers, and biological processes mediated by free radicals, Oxidation …

Nitric oxide (NO) is a molecule with pleiotropic effects in different tissues. NO is synthesized
by NO synthases (NOS), a family with four major types: endothelial, neuronal, inducible and …

In the past few years, nuclear DNA damage-sensing mechanisms activated by ionizing
radiation have been identified, including ATM/ATR and the DNA-dependent protein kinase …

Mitochondria constitute a primary locus for the intracellular formation and reactions of
peroxynitrite, and these interactions are recognized to contribute to the biological and …

Anticancer drugs continue to cause significant reductions in left ventricular ejection fraction
resulting in congestive heart failure. The best-known cardiotoxic agents are anthracyclines …