Current streamline of precision medicine uses histomorphological and molecular
information to indicate individual phenotypes and genotypes to achieve optimal outcome of …

Metastases arise from subsets of cancer cells that disseminate from the primary tumour,. The
ability of cancer cells to thrive in a new tissue site is influenced by genetic and epigenetic …

Lineage-tracing technologies based on Clustered Regularly Interspaced Short Palindromic
Repeats and CRISPR-associated protein 9 (CRISPR-Cas9) genome editing have emerged …

Changes in cellular identity (also known as histologic transformation or lineage plasticity)
can drive malignant progression and resistance to therapy in many cancers, including lung …

Recent advances in CRISPR-Cas9 engineering and single-cell assays have enabled the
simultaneous measurement of single-cell transcriptomic and phylogenetic profiles. However …

The therapeutic landscape across many cancers has dramatically improved since the
introduction of potent targeted agents and immunotherapy. Nonetheless, success of these …

Abstract Small Cell Lung Cancer (SCLC) is often a heterogeneous tumor, where dynamic
regulation of key transcription factors can drive multiple populations of phenotypically …

Change in cancer cell identity is well characterized as a mechanism of cancer progression
and acquired resistance to targeted therapies. Lung adenocarcinoma (LUAD) exhibits …