Sesquiterpenoids, and specifically sesquiterpene lactones from Asteraceae, may play a
highly significant role in human health, both as part of a balanced diet and as …

The cytotoxicity of chemotherapeutic agents is attributed to apoptosis. Acquired resistance to
the effects of chemotherapy has emerged as a significant impediment to effective cancer …

Traditional Chinese medicine commands a unique position among all traditional medicines
because of its 5000 years of history. Our own interest in natural products from traditional …

Highlights•This article highlights phases in parthenolide (PTL) lead anticancer drug
development.•PTL structure–activity relationship studies reveal properties required for …

Sesquiterpene lactones (SLs) are the active constituents of a variety of medicinal plants
used in traditional medicine for the treatment of inflammatory diseases. In recent years, the …

Sesquiterpene lactones are a large group of natural compounds, found primarily in plants of
Asteraceae family, with over 5000 structures reported to date. Within this family, genus …

Inflammation is a crucial and complex process that reestablishes the physiological state after
a noxious stimulus. In pathological conditions the inflammatory state may persist, leading to …

Natural products have always been exploited to promote health and served as a valuable
source for the discovery of new drugs. In this review, the great potential of natural …

Sesquiterpene lactones are a large group of secondary plant metabolites mostly known from
the Asteraceae family. They exert a broad variety of different biological activities. This review …

The quality of health care in Mesoamerica is influenced by its rich cultural diversity and
characterized by social inequalities. Especially indigenous and rural communities confront …