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Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules
The humoral arm of innate immunity includes diverse molecules with antibody-like functions,
some of which serve as disease severity biomarkers in coronavirus disease 2019 (COVID …
some of which serve as disease severity biomarkers in coronavirus disease 2019 (COVID …
Structural insights into the biological functions of the long pentraxin PTX3
AM Massimino, FE Colella, B Bottazzi… - Frontiers in …, 2023 - frontiersin.org
Soluble pattern recognition molecules (PRMs) are a heterogenous group of proteins that
recognize pathogen-and danger-associated molecular patterns (PAMPs and DAMPs …
recognize pathogen-and danger-associated molecular patterns (PAMPs and DAMPs …
[HTML][HTML] Genetic aspects of age-related macular degeneration and their therapeutic potential
Age-related macular degeneration (AMD) is a complex and multifactorial disease, resulting
from the interaction of environmental and genetic factors. The continuous discovery of …
from the interaction of environmental and genetic factors. The continuous discovery of …
Interplay between host humoral pattern recognition molecules controls undue immune responses against Aspergillus fumigatus
Abstract Pentraxin 3 (PTX3), a long pentraxin and a humoral pattern recognition molecule
(PRM), has been demonstrated to be protective against Aspergillus fumigatus, an airborne …
(PRM), has been demonstrated to be protective against Aspergillus fumigatus, an airborne …
[HTML][HTML] Role of complement in regulating inflammation processes in renal and prostate cancers
For decades, the complement system, the central pillar of innate immune response, was
recognized as a protective mechanism against cancer cells and the manipulation of …
recognized as a protective mechanism against cancer cells and the manipulation of …
C-reactive protein deficiency ameliorates experimental abdominal aortic aneurysms
Y Fu, H Liu, K Li, P Wei, N Alam, J Deng, M Li… - Frontiers in …, 2023 - frontiersin.org
Background C-reactive protein (CRP) levels are elevated in patients with abdominal aortic
aneurysms (AAA). However, it has not been investigated whether CRP contributes to AAA …
aneurysms (AAA). However, it has not been investigated whether CRP contributes to AAA …
MS4A4A modifies the risk of Alzheimer disease by regulating lipid metabolism and immune response in a unique microglia state
Genome-wide association studies (GWAS) have identified many modifiers of Alzheimer
disease (AD) risk enriched in microglia. Two of these modifiers are common variants in the …
disease (AD) risk enriched in microglia. Two of these modifiers are common variants in the …
The long pentraxin PTX3 as a new biomarker and pharmacological target in age-related macular degeneration and diabetic retinopathy
Age related macular degeneration (AMD) and diabetic retinopathy (DR) are multifactorial,
neurodegenerative and inflammatory diseases of the eye primarily involving cellular and …
neurodegenerative and inflammatory diseases of the eye primarily involving cellular and …
Glycogenolysis-Induced Astrocytic Ser**1 Expression Regulates Neuroinflammatory Effects on Hippocampal neuron
M Ishiyama, H Gotoh, S Oe, T Nomura, M Kitada… - Molecular …, 2025 - Springer
The bacterial pathogen, lipopolysaccharide (LPS), elicits microglial response and induces
cytokine secretion that subsequently activates astrocytes. Recent findings have indicated …
cytokine secretion that subsequently activates astrocytes. Recent findings have indicated …
The structural organisation of pentraxin-3 and its interactions with heavy chains of inter-α-inhibitor regulate crosslinking of the hyaluronan matrix
ABSTRACT Pentraxin-3 (PTX3) is an octameric protein, comprised of eight identical
protomers, that has diverse functions in reproductive biology, innate immunity and cancer …
protomers, that has diverse functions in reproductive biology, innate immunity and cancer …