Diverse heterochromatin states restricting cell identity and reprogramming
Heterochromatin is defined as a chromosomal domain harboring repressive H3K9me2/3 or
H3K27me3 histone modifications and relevant factors that physically compact the chromatin …
H3K27me3 histone modifications and relevant factors that physically compact the chromatin …
The chromatin signatures of enhancers and their dynamic regulation
A Barral, J Déjardin - Nucleus, 2023 - Taylor & Francis
Enhancers are cis-regulatory elements that can stimulate gene expression from distance,
and drive precise spatiotemporal gene expression profiles during development. Functional …
and drive precise spatiotemporal gene expression profiles during development. Functional …
Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair
M Kovatcheva, E Melendez, D Chondronasiou… - Nature …, 2023 - nature.com
Transient reprogramming by the expression of OCT4, SOX2, KLF4 and MYC (OSKM) is a
therapeutic strategy for tissue regeneration and rejuvenation, but little is known about its …
therapeutic strategy for tissue regeneration and rejuvenation, but little is known about its …
H3K36 methylation maintains cell identity by regulating opposing lineage programmes
The epigenetic mechanisms that maintain differentiated cell states remain incompletely
understood. Here we employed histone mutants to uncover a crucial role for H3K36 …
understood. Here we employed histone mutants to uncover a crucial role for H3K36 …
Cell-type differential targeting of SETDB1 prevents aberrant CTCF binding, chromatin loo**, and cis-regulatory interactions
PLF Tam, MF Cheung, LY Chan, D Leung - Nature Communications, 2024 - nature.com
SETDB1 is an essential histone methyltransferase that deposits histone H3 lysine 9
trimethylation (H3K9me3) to transcriptionally repress genes and repetitive elements. The …
trimethylation (H3K9me3) to transcriptionally repress genes and repetitive elements. The …
H3K9 methylation regulates heterochromatin silencing through incoherent feedforward loops
Histone H3 lysine-9 methylation (H3K9me) is a hallmark of the condensed and
transcriptionally silent heterochromatin. It remains unclear how H3K9me controls …
transcriptionally silent heterochromatin. It remains unclear how H3K9me controls …
Evidence for low nanocompaction of heterochromatin in living embryonic stem cells
C Dupont, D Chahar, A Trullo, T Gostan… - The EMBO …, 2023 - embopress.org
Despite advances in the identification of chromatin regulators and genome interactions, the
principles of higher‐order chromatin structure have remained elusive. Here, we applied …
principles of higher‐order chromatin structure have remained elusive. Here, we applied …
SAFB restricts contact domain boundaries associated with L1 chimeric transcription
Y Hong, L Bie, T Zhang, X Yan, G **, Z Chen, Y Wang… - Molecular Cell, 2024 - cell.com
Summary Long interspersed element-1 (LINE-1 or L1) comprises 17% of the human
genome, continuously generates genetic variations, and causes disease in certain cases …
genome, continuously generates genetic variations, and causes disease in certain cases …
An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability
In nucleosomes, histone N-terminal tails exist in dynamic equilibrium between
free/accessible and collapsed/DNA-bound states. The latter state is expected to impact …
free/accessible and collapsed/DNA-bound states. The latter state is expected to impact …
Genomic context-dependent histone H3K36 methylation by three Drosophila methyltransferases and implications for dedicated chromatin readers
M Jayakrishnan, M Havlová, V Veverka… - Nucleic Acids …, 2024 - academic.oup.com
Methylation of histone H3 at lysine 36 (H3K36me3) marks active chromatin. The mark is
interpreted by epigenetic readers that assist transcription and safeguard the integrity of the …
interpreted by epigenetic readers that assist transcription and safeguard the integrity of the …