As the eye's main load-bearing connective tissue, the sclera is centrally important to vision.
In addition to cooperatively maintaining refractive status with the cornea, the sclera must …

Glaucomatous optic neuropathy is the leading cause of irreversible blindness in the world.
The chronic disease is characterized by optic nerve degeneration and vision field loss. The …

The mechanical properties of the microstructural components of sclera are central to eye
physiology and pathology. Because these parameters are extremely difficult to measure …

Collagen fibers are the main load-bearing component of soft tissues but difficult to
incorporate into models. Whilst simplified homogenization models suffice for some …

Purpose: The purpose of this paper was to determine the architecture of the collagen fibers
of the peripapillary sclera, the retinal nerve fiber layer (RNFL), and Henle's fiber layer in vivo …

Purpose: To test the hypothesis that human, monkey, pig, sheep, cow, and goat eyes exhibit
circumferential, radial, and interweaving collagen architecture in the posterior sclera …

The mechanical properties of the sclera play a critical role in supporting the ocular structure
and maintaining its shape. However, non-invasive measurements to quantify scleral …

Myopia and glaucoma are both increasing in prevalence and are linked by an unknown
mechanism as many epidemiologic studies have identified moderate to high myopia as an …

Osteogenesis imperfecta (OI), a rare genetic connective tissue disorder, primarily arises from
pathogenic variants affecting the production or structure of collagen type I. In addition to …

Current tools lack the temporal or spatial resolution necessary to image many important
aspects of the architecture and dynamics of the optic nerve head (ONH). We evaluated the …