[HTML][HTML] Classifying the evolutionary and ecological features of neoplasms
Neoplasms change over time through a process of cell-level evolution, driven by genetic
and epigenetic alterations. However, the ecology of the microenvironment of a neoplastic …
and epigenetic alterations. However, the ecology of the microenvironment of a neoplastic …
Tumour immunotherapy: lessons from predator–prey theory
With the burgeoning use of immune-based treatments for cancer, never has there been a
greater need to understand the tumour microenvironment within which immune cells …
greater need to understand the tumour microenvironment within which immune cells …
Single-cell analysis tools for drug discovery and development
The genetic, functional or compositional heterogeneity of healthy and diseased tissues
presents major challenges in drug discovery and development. Such heterogeneity hinders …
presents major challenges in drug discovery and development. Such heterogeneity hinders …
Principles of seed banks and the emergence of complexity from dormancy
Across the tree of life, populations have evolved the capacity to contend with suboptimal
conditions by engaging in dormancy, whereby individuals enter a reversible state of reduced …
conditions by engaging in dormancy, whereby individuals enter a reversible state of reduced …
Tumour heterogeneity and the evolutionary trade-offs of cancer
Tumours vary in gene expression programmes and genetic alterations. Understanding this
diversity and its biological meaning requires a theoretical framework, which could in turn …
diversity and its biological meaning requires a theoretical framework, which could in turn …
Spatial heterogeneity and evolutionary dynamics modulate time to recurrence in continuous and adaptive cancer therapies
Abstract Treatment of advanced cancers has benefited from new agents that supplement or
bypass conventional therapies. However, even effective therapies fail as cancer cells deploy …
bypass conventional therapies. However, even effective therapies fail as cancer cells deploy …
Tumors produce glucocorticoids by metabolite recycling, not synthesis, and activate Tregs to promote growth
Glucocorticoids are steroid hormones with potent immunosuppressive properties. Their
primary source is the adrenals, where they are generated via de novo synthesis from …
primary source is the adrenals, where they are generated via de novo synthesis from …
Turning ecology and evolution against cancer
The fight against cancer has drawn researchers from a wide variety of disciplines, ranging
from molecular biology to physics, but the perspective of an ecological theorist has been …
from molecular biology to physics, but the perspective of an ecological theorist has been …
The pentose phosphate pathway as a potential target for cancer therapy
During cancer progression, cancer cells are repeatedly exposed to metabolic stress
conditions in a resource-limited environment which they must escape. Increasing evidence …
conditions in a resource-limited environment which they must escape. Increasing evidence …
Darwinian dynamics of intratumoral heterogeneity: not solely random mutations but also variable environmental selection forces
Spatial heterogeneity in tumors is generally thought to result from branching clonal evolution
driven by random mutations that accumulate during tumor development. However, this …
driven by random mutations that accumulate during tumor development. However, this …