Myocardial fibrosis is a significant global health problem associated with nearly all forms of
heart disease. Cardiac fibroblasts comprise an essential cell type in the heart that is …

Pericytes, spatially isolated contractile cells on capillaries, have been reported to control
cerebral blood flow physiologically, and to limit blood flow after ischaemia by constricting …

Signalling between cells of the neurovascular unit, or neurovascular coupling, is essential to
match local blood flow with neuronal activity. Pericytes interact with endothelial cells and …

Physical exercise can improve brain function and delay neurodegeneration; however, the
initial signal from muscle to brain is unknown. Here we show that the lactate receptor …

The proper delivery of blood is essential for healthy neuronal function. The anatomical
substrate for this precise mechanism is the neurovascular unit, which is formed by neurons …

Pericytes are unique, multi-functional mural cells localized at the abluminal side of the
perivascular space in microvessels. Originally discovered in 19th century, pericytes had …

Sleep is a complex physiological process that is regulated globally, regionally, and locally
by both cellular and molecular mechanisms. It occurs to some extent in all animals, although …

Prevalence of mental disorders, including major depressive disorder (MDD), bipolar
disorder (BD) and schizophrenia (SZ) are increasing at alarming rates in our societies …

Heart failure (HF) is a complex clinical syndrome with multiple interactions between the
failing myocardium and cerebral (dys‐) functions. Bi‐directional feedback interactions …

Reduced blood flow and impaired neurovascular coupling are recognized features of
glaucoma, the leading cause of irreversible blindness worldwide, but the mechanisms …